Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice

Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice

Abstract Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronchitis and emphysema. Owing to similarities between chronic bronchitis and the auto...

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Bibliographic Details
Main Authors: Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers, Estelle Cormet-Boyaka
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Respiratory Research
Subjects:
CFTR
Emphysema
Smoking
Aging
Online Access:http://link.springer.com/article/10.1186/s12931-019-1170-3

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