Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.

Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.

Therapeutic potential was evaluated in a rat model of myocardial infarction using nanofiber-expanded human cord blood derived hematopoietic stem cells (CD133+/CD34+) genetically modified with VEGF plus PDGF genes (VIP).Myocardial function was monitored every two weeks up to six weeks after therapy....

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Main Authors: Hiranmoy Das, Jon C George, Matthew Joseph, Manjusri Das, Nasreen Abdulhameed, Anna Blitz, Mahmood Khan, Ramasamy Sakthivel, Hai-Quan Mao, Brian D Hoit, Periannan Kuppusamy, Vincent J Pompili
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2752797?pdf=render

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