A new role for the nuclear basket network
Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have now demonstrated roles in genome regulation and maintenance from single cells to multicellular organisms. Both NPC proteins as well as compo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2017-11-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/a-new-role-for-the-nuclear-basket-network/ |
| _version_ | 1818528296007106560 |
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| author | Paola Gallardo Silvia Salas-Pino Rafael R. Daga |
| author_facet | Paola Gallardo Silvia Salas-Pino Rafael R. Daga |
| author_sort | Paola Gallardo |
| collection | DOAJ |
| description | Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have now demonstrated roles in genome regulation and maintenance from single cells to multicellular organisms. Both NPC proteins as well as components of the NPC basket act as dynamic scaffolds for silencing factors, and chromatin and cell cycle regulators. Components of the NPC basket also couple mRNA production and export, and prevent the exit of unprocessed mRNAs from the nucleus. Our recent work describes a novel function of the fission yeast nuclear basket component – the translocated promoter region (TPR) nucleoporin Alm1 – in proper localization of the proteasome to the nuclear envelope. Here we discuss how regulation of proteasome localization to the nuclear envelope by Alm1 is key to maintain kinetochores homeostasis and proper chromosome segregation. |
| first_indexed | 2024-12-11T06:47:56Z |
| format | Article |
| id | doaj.art-3f01c33b540946e28ab44b3e49aaad01 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-12-11T06:47:56Z |
| publishDate | 2017-11-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-3f01c33b540946e28ab44b3e49aaad012022-12-22T01:17:01ZengShared Science Publishers OGMicrobial Cell2311-26382017-11-0141242342510.15698/mic2017.12.604A new role for the nuclear basket networkPaola Gallardo0Silvia Salas-Pino1Rafael R. Daga2Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, Junta de Andalucia, Seville, Spain.Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, Junta de Andalucia, Seville, Spain.Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, Junta de Andalucia, Seville, Spain.Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have now demonstrated roles in genome regulation and maintenance from single cells to multicellular organisms. Both NPC proteins as well as components of the NPC basket act as dynamic scaffolds for silencing factors, and chromatin and cell cycle regulators. Components of the NPC basket also couple mRNA production and export, and prevent the exit of unprocessed mRNAs from the nucleus. Our recent work describes a novel function of the fission yeast nuclear basket component – the translocated promoter region (TPR) nucleoporin Alm1 – in proper localization of the proteasome to the nuclear envelope. Here we discuss how regulation of proteasome localization to the nuclear envelope by Alm1 is key to maintain kinetochores homeostasis and proper chromosome segregation.http://microbialcell.com/researcharticles/a-new-role-for-the-nuclear-basket-network/Alm1TPR nucleoporinsnuclear pore complexproteasomekinetochorefission yeast |
| spellingShingle | Paola Gallardo Silvia Salas-Pino Rafael R. Daga A new role for the nuclear basket network Microbial Cell Alm1 TPR nucleoporins nuclear pore complex proteasome kinetochore fission yeast |
| title | A new role for the nuclear basket network |
| title_full | A new role for the nuclear basket network |
| title_fullStr | A new role for the nuclear basket network |
| title_full_unstemmed | A new role for the nuclear basket network |
| title_short | A new role for the nuclear basket network |
| title_sort | new role for the nuclear basket network |
| topic | Alm1 TPR nucleoporins nuclear pore complex proteasome kinetochore fission yeast |
| url | http://microbialcell.com/researcharticles/a-new-role-for-the-nuclear-basket-network/ |
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