Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study
Abstract Background Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive changes. Methods We investigated the change in 18F-Flut...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-022-00928-5 |
| _version_ | 1811273604525981696 |
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| author | Elina Rauhala Jarkko Johansson Mira Karrasch Olli Eskola Tuula Tolvanen Riitta Parkkola Kirsi A. Virtanen Juha O. Rinne |
| author_facet | Elina Rauhala Jarkko Johansson Mira Karrasch Olli Eskola Tuula Tolvanen Riitta Parkkola Kirsi A. Virtanen Juha O. Rinne |
| author_sort | Elina Rauhala |
| collection | DOAJ |
| description | Abstract Background Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive changes. Methods We investigated the change in 18F-Flutemetamol uptake and cognitive impairment in aMCI patients over time up to 3 years which enabled us to investigate possible association between changes in brain amyloid load and cognition over time. Thirty-four patients with aMCI (mean age 73.4 years, SD 6.6) were examined with 18F-Flutemetamol PET scan, brain MRI and cognitive tests at baseline and after 3-year follow-up or earlier if the patient had converted to Alzheimer´s disease (AD). 18F-Flutemetamol data were analyzed both with automated region-of-interest analysis and voxel-based statistical parametric mapping. Results 18F-flutemetamol uptake increased during the follow-up, and the increase was significantly higher in patients who were amyloid positive at baseline as compared to the amyloid-negative ones. At follow-up, there was a significant association between 18F-Flutemetamol uptake and MMSE, logical memory I (immediate recall), logical memory II (delayed recall) and verbal fluency. An association was seen between the increase in 18F-Flutemetamol uptake and decline in MMSE and logical memory I scores. Conclusions In the early phase of aMCI, presence of amyloid pathology at baseline strongly predicted amyloid accumulation during follow-up, which was further paralleled by cognitive declines. Inversely, some of our patients remained amyloid negative also at the end of the study without significant change in 18F-Flutemetamol uptake or cognition. Future studies with longer follow-up are needed to distinguish whether the underlying pathophysiology of aMCI in such patients is other than AD. |
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| format | Article |
| id | doaj.art-3f03f8e1508e4f8ab0380db0abe4eac3 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-04-12T23:02:18Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-3f03f8e1508e4f8ab0380db0abe4eac32022-12-22T03:13:00ZengSpringerOpenEJNMMI Research2191-219X2022-09-011211810.1186/s13550-022-00928-5Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up studyElina Rauhala0Jarkko Johansson1Mira Karrasch2Olli Eskola3Tuula Tolvanen4Riitta Parkkola5Kirsi A. Virtanen6Juha O. Rinne7Clinical Neurosciences, Faculty of Medicine, Turku University Hospital, University of Turku and NeurocenterTurku PET Centre, Turku University HospitalDepartment of Psychology, Åbo Akademi UniversityTurku PET Centre, University of TurkuTurku PET Centre, University of TurkuDepartment of Radiology, University of Turku and Turku University HospitalTurku PET Centre, Turku University HospitalTurku PET Centre, Turku University HospitalAbstract Background Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive changes. Methods We investigated the change in 18F-Flutemetamol uptake and cognitive impairment in aMCI patients over time up to 3 years which enabled us to investigate possible association between changes in brain amyloid load and cognition over time. Thirty-four patients with aMCI (mean age 73.4 years, SD 6.6) were examined with 18F-Flutemetamol PET scan, brain MRI and cognitive tests at baseline and after 3-year follow-up or earlier if the patient had converted to Alzheimer´s disease (AD). 18F-Flutemetamol data were analyzed both with automated region-of-interest analysis and voxel-based statistical parametric mapping. Results 18F-flutemetamol uptake increased during the follow-up, and the increase was significantly higher in patients who were amyloid positive at baseline as compared to the amyloid-negative ones. At follow-up, there was a significant association between 18F-Flutemetamol uptake and MMSE, logical memory I (immediate recall), logical memory II (delayed recall) and verbal fluency. An association was seen between the increase in 18F-Flutemetamol uptake and decline in MMSE and logical memory I scores. Conclusions In the early phase of aMCI, presence of amyloid pathology at baseline strongly predicted amyloid accumulation during follow-up, which was further paralleled by cognitive declines. Inversely, some of our patients remained amyloid negative also at the end of the study without significant change in 18F-Flutemetamol uptake or cognition. Future studies with longer follow-up are needed to distinguish whether the underlying pathophysiology of aMCI in such patients is other than AD.https://doi.org/10.1186/s13550-022-00928-5FlutemetamolPositron emission tomographyMild cognitive impairmentAlzheimerAmyloid PETFollow-up |
| spellingShingle | Elina Rauhala Jarkko Johansson Mira Karrasch Olli Eskola Tuula Tolvanen Riitta Parkkola Kirsi A. Virtanen Juha O. Rinne Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study EJNMMI Research Flutemetamol Positron emission tomography Mild cognitive impairment Alzheimer Amyloid PET Follow-up |
| title | Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study |
| title_full | Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study |
| title_fullStr | Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study |
| title_full_unstemmed | Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study |
| title_short | Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study |
| title_sort | change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment a 3 year follow up study |
| topic | Flutemetamol Positron emission tomography Mild cognitive impairment Alzheimer Amyloid PET Follow-up |
| url | https://doi.org/10.1186/s13550-022-00928-5 |
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