Single Cell in a Gravity Field
The exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; h...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/12/10/1601 |
| _version_ | 1797471988965441536 |
|---|---|
| author | Irina V. Ogneva |
| author_facet | Irina V. Ogneva |
| author_sort | Irina V. Ogneva |
| collection | DOAJ |
| description | The exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; however, the mechanism of reception of the altered gravity and transduction of this signal, leading to the formation of an adaptive pattern of the cell, is still poorly understood. At the same time, most of the negative changes that occur in early embryos when the force of gravity changes almost disappear by the time the new organism is born. This review is devoted to the responses of early embryos and stem cells, as well as terminally differentiated germ cells, to changes in gravity. An attempt was made to generalize the data presented in the literature and propose a possible unified mechanism for the reception by a single cell of an increase and decrease in gravity based on various deformations of the cortical cytoskeleton. |
| first_indexed | 2024-03-09T19:55:50Z |
| format | Article |
| id | doaj.art-3f04b56f0e52464a97abaecfd01a3db7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T19:55:50Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3f04b56f0e52464a97abaecfd01a3db72023-11-24T00:57:03ZengMDPI AGLife2075-17292022-10-011210160110.3390/life12101601Single Cell in a Gravity FieldIrina V. Ogneva0Cell Biophysics Laboratory, State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, 76a, Khoroshevskoyoe Shosse, 123007 Moscow, RussiaThe exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; however, the mechanism of reception of the altered gravity and transduction of this signal, leading to the formation of an adaptive pattern of the cell, is still poorly understood. At the same time, most of the negative changes that occur in early embryos when the force of gravity changes almost disappear by the time the new organism is born. This review is devoted to the responses of early embryos and stem cells, as well as terminally differentiated germ cells, to changes in gravity. An attempt was made to generalize the data presented in the literature and propose a possible unified mechanism for the reception by a single cell of an increase and decrease in gravity based on various deformations of the cortical cytoskeleton.https://www.mdpi.com/2075-1729/12/10/1601cellular mechanoreceptioncellular mechanotransductionspace flightmicrogravityhypergravityearly embryo |
| spellingShingle | Irina V. Ogneva Single Cell in a Gravity Field Life cellular mechanoreception cellular mechanotransduction space flight microgravity hypergravity early embryo |
| title | Single Cell in a Gravity Field |
| title_full | Single Cell in a Gravity Field |
| title_fullStr | Single Cell in a Gravity Field |
| title_full_unstemmed | Single Cell in a Gravity Field |
| title_short | Single Cell in a Gravity Field |
| title_sort | single cell in a gravity field |
| topic | cellular mechanoreception cellular mechanotransduction space flight microgravity hypergravity early embryo |
| url | https://www.mdpi.com/2075-1729/12/10/1601 |
| work_keys_str_mv | AT irinavogneva singlecellinagravityfield |