Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.

Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.

Fetal exposure to hyperglycemia impacts negatively kidney development and function.Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in peripheral blood cells and whether those alterations are related to impai...

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Hlavní autoři: Jean-François Gautier, Raphaël Porcher, Charbel Abi Khalil, Naima Bellili-Munoz, Lila Sabrina Fetita, Florence Travert, Simeon-Pierre Choukem, Jean-Pierre Riveline, Samy Hadjadj, Etienne Larger, Philippe Boudou, Bertrand Blondeau, Ronan Roussel, Pascal Ferré, Eric Ravussin, François Rouzet, Michel Marre
Médium: Článek
Jazyk:English
Vydáno: Public Library of Science (PLoS) 2015-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC4530883?pdf=render

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http://europepmc.org/articles/PMC4530883?pdf=render

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