Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital
Objective: To study lipid profile in patients of subclinical hypothyroidism and compare the same with matched controls. Materials and Methods: This single exposure observational study was conducted from June 2010 to March 2011 at our department of Biochemistry. Thirty patients with subclinical hypot...
| Главные авторы: | , , , |
|---|---|
| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Серии: | CHRISMED Journal of Health and Research |
| Предметы: | |
| Online-ссылка: | http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=4;spage=266;epage=270;aulast=Guntaka |
| _version_ | 1829100364941492224 |
|---|---|
| author | Mounika Guntaka Babulreddy Hanmayyagari Manne Rosaline V Nagesh |
| author_facet | Mounika Guntaka Babulreddy Hanmayyagari Manne Rosaline V Nagesh |
| author_sort | Mounika Guntaka |
| collection | DOAJ |
| description | Objective: To study lipid profile in patients of subclinical hypothyroidism and compare the same with matched controls. Materials and Methods: This single exposure observational study was conducted from June 2010 to March 2011 at our department of Biochemistry. Thirty patients with subclinical hypothyroidism were selected after careful exclusion; lipid profile was compared with matched controls. Statistical analysis was done with Student′s t test. All values were expressed as mean ± SEM, where value of P ≤ 0.05 was considered statistically significant. Results: Between the two groups (group I - controls vs. group II - cases), the values were as follows: Mean serum total T 3 value was 115.03 ± 28.22 ng/dl vs. 107.13 ± 35.26 ng/dl (P = 0.3474); mean total T 4 was 7.0787 ± 1.6952 μg/dl vs. 6.8633 ± 1.3106 μg/dl (P = 0.532); mean TSH was 3.1730 ± 1.2772 μIU/ml vs. 9.7607 ± 4.1853 μIU/ml (P < 0.0001). Lipid profile pattern (group I vs. group II) was as follows: Mean total cholesterol (TC) 127.50 ± 7.18 mg/dl vs. 163.07 ± 41.32 mg/dl (P < 0.0001), mean triglycerides (TG) is 135.67 ± 13.84 mg/dl vs. 147.90 ± 66.27 mg/dl (P = 0.3231), low-density lipoprotein (LDL)-cholesterol is 61.17 ± 7.60 mg/dl vs. 99.83 ± 32.24 mg/dl (P < 0.0001), high-density lipoprotein (HDL)-cholesterol 39.13 ± 6.66 mg/dl vs. 35.27 ± 8.63 mg/dl (P = 0.0701), very low-density lipoprotein (VLDL) levels are 33.533 ± 14.375 mg/dl vs. 31.077 ± 14.202 mg/dl (P = 0.5235). Conclusion: Subclinical hypothyroidism is associated with increased serum total cholesterol and LDL-Cholesterol levels. Therefore, there is a potential association between Subclinical hypothyroidism and atherosclerosis. |
| first_indexed | 2024-12-10T22:32:13Z |
| format | Article |
| id | doaj.art-3f0c09a247a04d1e8fe7576d54e2ffd6 |
| institution | Directory Open Access Journal |
| issn | 2348-3334 2348-506X |
| language | English |
| last_indexed | 2024-12-10T22:32:13Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | CHRISMED Journal of Health and Research |
| spelling | doaj.art-3f0c09a247a04d1e8fe7576d54e2ffd62022-12-22T01:31:02ZengWolters Kluwer Medknow PublicationsCHRISMED Journal of Health and Research2348-33342348-506X2014-01-011426627010.4103/2348-3334.143014Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospitalMounika GuntakaBabulreddy HanmayyagariManne RosalineV NageshObjective: To study lipid profile in patients of subclinical hypothyroidism and compare the same with matched controls. Materials and Methods: This single exposure observational study was conducted from June 2010 to March 2011 at our department of Biochemistry. Thirty patients with subclinical hypothyroidism were selected after careful exclusion; lipid profile was compared with matched controls. Statistical analysis was done with Student′s t test. All values were expressed as mean ± SEM, where value of P ≤ 0.05 was considered statistically significant. Results: Between the two groups (group I - controls vs. group II - cases), the values were as follows: Mean serum total T 3 value was 115.03 ± 28.22 ng/dl vs. 107.13 ± 35.26 ng/dl (P = 0.3474); mean total T 4 was 7.0787 ± 1.6952 μg/dl vs. 6.8633 ± 1.3106 μg/dl (P = 0.532); mean TSH was 3.1730 ± 1.2772 μIU/ml vs. 9.7607 ± 4.1853 μIU/ml (P < 0.0001). Lipid profile pattern (group I vs. group II) was as follows: Mean total cholesterol (TC) 127.50 ± 7.18 mg/dl vs. 163.07 ± 41.32 mg/dl (P < 0.0001), mean triglycerides (TG) is 135.67 ± 13.84 mg/dl vs. 147.90 ± 66.27 mg/dl (P = 0.3231), low-density lipoprotein (LDL)-cholesterol is 61.17 ± 7.60 mg/dl vs. 99.83 ± 32.24 mg/dl (P < 0.0001), high-density lipoprotein (HDL)-cholesterol 39.13 ± 6.66 mg/dl vs. 35.27 ± 8.63 mg/dl (P = 0.0701), very low-density lipoprotein (VLDL) levels are 33.533 ± 14.375 mg/dl vs. 31.077 ± 14.202 mg/dl (P = 0.5235). Conclusion: Subclinical hypothyroidism is associated with increased serum total cholesterol and LDL-Cholesterol levels. Therefore, there is a potential association between Subclinical hypothyroidism and atherosclerosis.http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=4;spage=266;epage=270;aulast=GuntakaCardiovascular risklipid profilesubclinical hypothyroidismthyroid stimulating hormone |
| spellingShingle | Mounika Guntaka Babulreddy Hanmayyagari Manne Rosaline V Nagesh Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital CHRISMED Journal of Health and Research Cardiovascular risk lipid profile subclinical hypothyroidism thyroid stimulating hormone |
| title | Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital |
| title_full | Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital |
| title_fullStr | Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital |
| title_full_unstemmed | Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital |
| title_short | Lipid profile in subclinical hypothyroidism: A biochemical study from tertiary care hospital |
| title_sort | lipid profile in subclinical hypothyroidism a biochemical study from tertiary care hospital |
| topic | Cardiovascular risk lipid profile subclinical hypothyroidism thyroid stimulating hormone |
| url | http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=4;spage=266;epage=270;aulast=Guntaka |
| work_keys_str_mv | AT mounikaguntaka lipidprofileinsubclinicalhypothyroidismabiochemicalstudyfromtertiarycarehospital AT babulreddyhanmayyagari lipidprofileinsubclinicalhypothyroidismabiochemicalstudyfromtertiarycarehospital AT mannerosaline lipidprofileinsubclinicalhypothyroidismabiochemicalstudyfromtertiarycarehospital AT vnagesh lipidprofileinsubclinicalhypothyroidismabiochemicalstudyfromtertiarycarehospital |