H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry
Hydrogen sulfide (H<sub>2</sub>S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monox...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/12/1899 |
| _version_ | 1797506435747151872 |
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| author | Elisa Magli Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese |
| author_facet | Elisa Magli Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese |
| author_sort | Elisa Magli |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub>2</sub>S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub>2</sub>S levels has a potential therapeutic value. Consequently, synthetic H<sub>2</sub>S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub>2</sub>S donors; furthermore, herein we discuss their preparation, the H<sub>2</sub>S-releasing mechanisms, and their -biological applications. |
| first_indexed | 2024-03-10T04:32:38Z |
| format | Article |
| id | doaj.art-3f0d2b2493524ef4939b8bf200265b98 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T04:32:38Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3f0d2b2493524ef4939b8bf200265b982023-11-23T04:00:59ZengMDPI AGBiomolecules2218-273X2021-12-011112189910.3390/biom11121899H<sub>2</sub>S Donors and Their Use in Medicinal ChemistryElisa Magli0Elisa Perissutti1Vincenzo Santagada2Giuseppe Caliendo3Angela Corvino4Gianluca Esposito5Giovanna Esposito6Ferdinando Fiorino7Marco Migliaccio8Antonia Scognamiglio9Beatrice Severino10Rosa Sparaco11Francesco Frecentese12Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, ItalyHydrogen sulfide (H<sub>2</sub>S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub>2</sub>S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub>2</sub>S levels has a potential therapeutic value. Consequently, synthetic H<sub>2</sub>S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub>2</sub>S donors; furthermore, herein we discuss their preparation, the H<sub>2</sub>S-releasing mechanisms, and their -biological applications.https://www.mdpi.com/2218-273X/11/12/1899hydrogen sulfidenatural H<sub>2</sub>S donorssynthetic H<sub>2</sub>S donorsH<sub>2</sub>S releasemedicinal chemistry |
| spellingShingle | Elisa Magli Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry Biomolecules hydrogen sulfide natural H<sub>2</sub>S donors synthetic H<sub>2</sub>S donors H<sub>2</sub>S release medicinal chemistry |
| title | H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry |
| title_full | H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry |
| title_fullStr | H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry |
| title_full_unstemmed | H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry |
| title_short | H<sub>2</sub>S Donors and Their Use in Medicinal Chemistry |
| title_sort | h sub 2 sub s donors and their use in medicinal chemistry |
| topic | hydrogen sulfide natural H<sub>2</sub>S donors synthetic H<sub>2</sub>S donors H<sub>2</sub>S release medicinal chemistry |
| url | https://www.mdpi.com/2218-273X/11/12/1899 |
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