LightSpot<sup>®</sup>-FL-1 Fluorescent Probe: An Innovative Tool for Cancer Drug Resistance Analysis by Direct Detection and Quantification of the P-glycoprotein (P-gp) on Monolayer Culture and Spheroid Triple Negative Breast Cancer Models

LightSpot<sup>®</sup>-FL-1 Fluorescent Probe: An Innovative Tool for Cancer Drug Resistance Analysis by Direct Detection and Quantification of the P-glycoprotein (P-gp) on Monolayer Culture and Spheroid Triple Negative Breast Cancer Models

P-gp is the most widely studied MDR protein conferring cellular resistance to many standard or targeted therapeutic agents. For this reason, P-gp chemoresistance evaluation, established before or during chemotherapy, can be very relevant in order to optimize the efficacy of treatments, particularly...

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Bibliographic Details
Main Authors: Antoine Goisnard, Pierre Daumar, Clémence Dubois, Corinne Aubel, Manon Roux, Marie Depresle, Jean Gauthier, Bernard Vidalinc, Frédérique Penault-Llorca, Emmanuelle Mounetou, Mahchid Bamdad
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
multidrug resistance
P-gp staining
LightSpot<sup>®</sup>-FL-1 cell-permeant fluorescent probe
triple-negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/13/16/4050

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