Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study
Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evoluti...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/23/15350 |
_version_ | 1797462993549656064 |
---|---|
author | Álvaro Aparisi Marta Martín-Fernández Cristina Ybarra-Falcón José Francisco Gil Manuel Carrasco-Moraleja Pedro Martínez-Paz Iván Cusácovich Hugo Gonzalo-Benito Raúl Fuertes Marta Marcos-Mangas Carolina Iglesias-Echeverría J. Alberto San Román Eduardo Tamayo David Andaluz-Ojeda Álvaro Tamayo-Velasco |
author_facet | Álvaro Aparisi Marta Martín-Fernández Cristina Ybarra-Falcón José Francisco Gil Manuel Carrasco-Moraleja Pedro Martínez-Paz Iván Cusácovich Hugo Gonzalo-Benito Raúl Fuertes Marta Marcos-Mangas Carolina Iglesias-Echeverría J. Alberto San Román Eduardo Tamayo David Andaluz-Ojeda Álvaro Tamayo-Velasco |
author_sort | Álvaro Aparisi |
collection | DOAJ |
description | Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; <i>p</i> = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; <i>p</i> = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017–1.110; <i>p</i> = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; <i>p</i> = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; <i>p</i> = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile. |
first_indexed | 2024-03-09T17:44:22Z |
format | Article |
id | doaj.art-3f0ddc69399b4fafa9a83b80c19e158c |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T17:44:22Z |
publishDate | 2022-12-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-3f0ddc69399b4fafa9a83b80c19e158c2023-11-24T11:17:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231535010.3390/ijms232315350Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up StudyÁlvaro Aparisi0Marta Martín-Fernández1Cristina Ybarra-Falcón2José Francisco Gil3Manuel Carrasco-Moraleja4Pedro Martínez-Paz5Iván Cusácovich6Hugo Gonzalo-Benito7Raúl Fuertes8Marta Marcos-Mangas9Carolina Iglesias-Echeverría10J. Alberto San Román11Eduardo Tamayo12David Andaluz-Ojeda13Álvaro Tamayo-Velasco14Unidad de Cardiología Intervencionista, Servicio de Cardiología, Hospital del Mar, 08003 Barcelona, SpainDepartamento de Medicina, Toxicología y Dermatología, Facultad de Medicina, Universidad de Valladolid, 47002 Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, SpainServicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, SpainServicio de Radiología, Hospital Universitario la Princesa, 28006 Madrid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainServicio de Cardiología, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, SpainServicio de Medicina Intensiva, Hospital Universitario HM Sanchinarro, Hospitales Madrid, 28050 Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, SpainRecent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; <i>p</i> = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; <i>p</i> = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017–1.110; <i>p</i> = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; <i>p</i> = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; <i>p</i> = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile.https://www.mdpi.com/1422-0067/23/23/15350total cholesterollipoproteinslipid peroxidationoxidative stressCOVID-19inflammation |
spellingShingle | Álvaro Aparisi Marta Martín-Fernández Cristina Ybarra-Falcón José Francisco Gil Manuel Carrasco-Moraleja Pedro Martínez-Paz Iván Cusácovich Hugo Gonzalo-Benito Raúl Fuertes Marta Marcos-Mangas Carolina Iglesias-Echeverría J. Alberto San Román Eduardo Tamayo David Andaluz-Ojeda Álvaro Tamayo-Velasco Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study International Journal of Molecular Sciences total cholesterol lipoproteins lipid peroxidation oxidative stress COVID-19 inflammation |
title | Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study |
title_full | Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study |
title_fullStr | Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study |
title_full_unstemmed | Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study |
title_short | Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study |
title_sort | dyslipidemia and inflammation as hallmarks of oxidative stress in covid 19 a follow up study |
topic | total cholesterol lipoproteins lipid peroxidation oxidative stress COVID-19 inflammation |
url | https://www.mdpi.com/1422-0067/23/23/15350 |
work_keys_str_mv | AT alvaroaparisi dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT martamartinfernandez dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT cristinaybarrafalcon dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT josefranciscogil dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT manuelcarrascomoraleja dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT pedromartinezpaz dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT ivancusacovich dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT hugogonzalobenito dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT raulfuertes dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT martamarcosmangas dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT carolinaiglesiasecheverria dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT jalbertosanroman dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT eduardotamayo dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT davidandaluzojeda dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy AT alvarotamayovelasco dyslipidemiaandinflammationashallmarksofoxidativestressincovid19afollowupstudy |