Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
<p>Abstract</p> <p>In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus g...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-03-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/4/1/18 |
| _version_ | 1818758610650398720 |
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| author | Burny Arsène Defoiche Julien Bouzar Amel-Baya Balon Hervé Vandermeers Fabian Nigro Annamaria Burteau Catherine Boxus Mathieu Florins Arnaud Gillet Nicolas Reichert Michal Kettmann Richard Willems Luc |
| author_facet | Burny Arsène Defoiche Julien Bouzar Amel-Baya Balon Hervé Vandermeers Fabian Nigro Annamaria Burteau Catherine Boxus Mathieu Florins Arnaud Gillet Nicolas Reichert Michal Kettmann Richard Willems Luc |
| author_sort | Burny Arsène |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.</p> |
| first_indexed | 2024-12-18T06:29:34Z |
| format | Article |
| id | doaj.art-3f0f97706ae641ac9155369bd8960f37 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-18T06:29:34Z |
| publishDate | 2007-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-3f0f97706ae641ac9155369bd8960f372022-12-21T21:17:57ZengBMCRetrovirology1742-46902007-03-01411810.1186/1742-4690-4-18Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in humanBurny ArsèneDefoiche JulienBouzar Amel-BayaBalon HervéVandermeers FabianNigro AnnamariaBurteau CatherineBoxus MathieuFlorins ArnaudGillet NicolasReichert MichalKettmann RichardWillems Luc<p>Abstract</p> <p>In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.</p>http://www.retrovirology.com/content/4/1/18 |
| spellingShingle | Burny Arsène Defoiche Julien Bouzar Amel-Baya Balon Hervé Vandermeers Fabian Nigro Annamaria Burteau Catherine Boxus Mathieu Florins Arnaud Gillet Nicolas Reichert Michal Kettmann Richard Willems Luc Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human Retrovirology |
| title | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
| title_full | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
| title_fullStr | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
| title_full_unstemmed | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
| title_short | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
| title_sort | mechanisms of leukemogenesis induced by bovine leukemia virus prospects for novel anti retroviral therapies in human |
| url | http://www.retrovirology.com/content/4/1/18 |
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