Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study
Oxytocin (OT) affects many behavioral, psychological, and physiological functions, including appetite and body weight regulation. Central and peripheral OT levels are markedly affected by gonadal steroids, especially estrogen, and the anorectic effects of estrogen are partially mediated by OT in rod...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5350 |
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| author | Ayaka Tachibana Yuri Yamamoto Hiroki Noguchi Asuka Takeda Kou Tamura Hidenori Aoki Saki Minato Maimi Uchishiba Shota Yamamoto Shuhei Kamada Atsuko Yoshida Riyo Kinouchi Kanako Yoshida Takeshi Iwasa |
| author_facet | Ayaka Tachibana Yuri Yamamoto Hiroki Noguchi Asuka Takeda Kou Tamura Hidenori Aoki Saki Minato Maimi Uchishiba Shota Yamamoto Shuhei Kamada Atsuko Yoshida Riyo Kinouchi Kanako Yoshida Takeshi Iwasa |
| author_sort | Ayaka Tachibana |
| collection | DOAJ |
| description | Oxytocin (OT) affects many behavioral, psychological, and physiological functions, including appetite and body weight regulation. Central and peripheral OT levels are markedly affected by gonadal steroids, especially estrogen, and the anorectic effects of estrogen are partially mediated by OT in rodents. In this study, the relationship between the estrogen milieu and serum OT levels was evaluated in women of reproductive age under physiological (<i>n</i> = 9) and supraphysiological estrogenic conditions (<i>n</i> = 7). Consequently, it was found that serum OT levels were increased in physiological (the ovulatory phase) and supraphysiological (on the day of the human chorionic gonadotropin trigger in an ovarian stimulation cycle) estrogenic conditions, and that serum OT levels were positively correlated with serum estradiol levels. On the other hand, serum OT levels were negatively correlated with serum progesterone levels, and there was no correlation between serum and follicular OT levels. These results suggest that OT levels may be positively and negatively regulated by estrogen and progesterone, respectively, in humans. However, the physiological roles of these actions of gonadal steroids on OT remain unclear. |
| first_indexed | 2024-03-09T16:00:09Z |
| format | Article |
| id | doaj.art-3f12319649ac45a1a67abe5a224cd618 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:09Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3f12319649ac45a1a67abe5a224cd6182023-11-24T17:09:47ZengMDPI AGNutrients2072-66432022-12-011424535010.3390/nu14245350Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary StudyAyaka Tachibana0Yuri Yamamoto1Hiroki Noguchi2Asuka Takeda3Kou Tamura4Hidenori Aoki5Saki Minato6Maimi Uchishiba7Shota Yamamoto8Shuhei Kamada9Atsuko Yoshida10Riyo Kinouchi11Kanako Yoshida12Takeshi Iwasa13Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-0808, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanOxytocin (OT) affects many behavioral, psychological, and physiological functions, including appetite and body weight regulation. Central and peripheral OT levels are markedly affected by gonadal steroids, especially estrogen, and the anorectic effects of estrogen are partially mediated by OT in rodents. In this study, the relationship between the estrogen milieu and serum OT levels was evaluated in women of reproductive age under physiological (<i>n</i> = 9) and supraphysiological estrogenic conditions (<i>n</i> = 7). Consequently, it was found that serum OT levels were increased in physiological (the ovulatory phase) and supraphysiological (on the day of the human chorionic gonadotropin trigger in an ovarian stimulation cycle) estrogenic conditions, and that serum OT levels were positively correlated with serum estradiol levels. On the other hand, serum OT levels were negatively correlated with serum progesterone levels, and there was no correlation between serum and follicular OT levels. These results suggest that OT levels may be positively and negatively regulated by estrogen and progesterone, respectively, in humans. However, the physiological roles of these actions of gonadal steroids on OT remain unclear.https://www.mdpi.com/2072-6643/14/24/5350oxytocinestrogenIVF/ICS |
| spellingShingle | Ayaka Tachibana Yuri Yamamoto Hiroki Noguchi Asuka Takeda Kou Tamura Hidenori Aoki Saki Minato Maimi Uchishiba Shota Yamamoto Shuhei Kamada Atsuko Yoshida Riyo Kinouchi Kanako Yoshida Takeshi Iwasa Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study Nutrients oxytocin estrogen IVF/ICS |
| title | Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study |
| title_full | Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study |
| title_fullStr | Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study |
| title_full_unstemmed | Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study |
| title_short | Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study |
| title_sort | changes in serum oxytocin levels under physiological and supraphysiological gonadal steroid hormone conditions in women of reproductive age a preliminary study |
| topic | oxytocin estrogen IVF/ICS |
| url | https://www.mdpi.com/2072-6643/14/24/5350 |
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