Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes
Natural products from actinomycetes serve as a crucial source of clinical pharmaceuticals, especially antibiotics and anticancer agents. Among them, polycyclic xanthones belong to a growing group of highly oxygenated aromatic polyketides with a xanthone-containing angular hexacyclic framework. These...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.922089/full |
| _version_ | 1818517961710764032 |
|---|---|
| author | Hui-Qing Yu Gang Li Hong-Xiang Lou Hong-Xiang Lou |
| author_facet | Hui-Qing Yu Gang Li Hong-Xiang Lou Hong-Xiang Lou |
| author_sort | Hui-Qing Yu |
| collection | DOAJ |
| description | Natural products from actinomycetes serve as a crucial source of clinical pharmaceuticals, especially antibiotics and anticancer agents. Among them, polycyclic xanthones belong to a growing group of highly oxygenated aromatic polyketides with a xanthone-containing angular hexacyclic framework. These biosynthetically unique small molecules are of great interest due to their wide spectrum of biological activities, especially the remarkable antibacterial activity against gram-positive bacteria and the significant antineoplastic effects toward various cancer cells at nanomolar concentrations. Their complex structures and significant bioactivities have aroused considerable attention in the chemical and biological communities in recent decades. This review covers the isolation, the biosynthesis, and the biological studies toward these structurally complex and biologically active molecules. |
| first_indexed | 2024-12-11T01:03:35Z |
| format | Article |
| id | doaj.art-3f12d8565be64ccb82221055a29039ad |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T01:03:35Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3f12d8565be64ccb82221055a29039ad2022-12-22T01:26:14ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-07-011310.3389/fmicb.2022.922089922089Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From ActinomycetesHui-Qing Yu0Gang Li1Hong-Xiang Lou2Hong-Xiang Lou3School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, ChinaDepartment of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, ChinaDepartment of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, ChinaNatural products from actinomycetes serve as a crucial source of clinical pharmaceuticals, especially antibiotics and anticancer agents. Among them, polycyclic xanthones belong to a growing group of highly oxygenated aromatic polyketides with a xanthone-containing angular hexacyclic framework. These biosynthetically unique small molecules are of great interest due to their wide spectrum of biological activities, especially the remarkable antibacterial activity against gram-positive bacteria and the significant antineoplastic effects toward various cancer cells at nanomolar concentrations. Their complex structures and significant bioactivities have aroused considerable attention in the chemical and biological communities in recent decades. This review covers the isolation, the biosynthesis, and the biological studies toward these structurally complex and biologically active molecules.https://www.frontiersin.org/articles/10.3389/fmicb.2022.922089/fullactinomycetesnatural productspolycyclic xanthonesbiosynthesisbioactivities |
| spellingShingle | Hui-Qing Yu Gang Li Hong-Xiang Lou Hong-Xiang Lou Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes Frontiers in Microbiology actinomycetes natural products polycyclic xanthones biosynthesis bioactivities |
| title | Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes |
| title_full | Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes |
| title_fullStr | Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes |
| title_full_unstemmed | Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes |
| title_short | Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes |
| title_sort | isolation biosynthesis and biological activity of polycyclic xanthones from actinomycetes |
| topic | actinomycetes natural products polycyclic xanthones biosynthesis bioactivities |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.922089/full |
| work_keys_str_mv | AT huiqingyu isolationbiosynthesisandbiologicalactivityofpolycyclicxanthonesfromactinomycetes AT gangli isolationbiosynthesisandbiologicalactivityofpolycyclicxanthonesfromactinomycetes AT hongxianglou isolationbiosynthesisandbiologicalactivityofpolycyclicxanthonesfromactinomycetes AT hongxianglou isolationbiosynthesisandbiologicalactivityofpolycyclicxanthonesfromactinomycetes |