Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis
Background and purpose: Though controversial, many clinical trials have been conducted to evaluate the efficacy of intravenous immunoglobulins (IVIG) in COVID-19 cases. Therefore, a systematic review and meta-analysis have been performed to evaluate the efficacy of IVIG in the treatment of COVID-19...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=4;spage=346;epage=357;aulast=Fatemi |
| _version_ | 1797773670962167808 |
|---|---|
| author | Behzad Fatemi Soheila Rezaei Mohammad Peikanpour Farzaneh Dastan Ali Saffaei |
| author_facet | Behzad Fatemi Soheila Rezaei Mohammad Peikanpour Farzaneh Dastan Ali Saffaei |
| author_sort | Behzad Fatemi |
| collection | DOAJ |
| description | Background and purpose: Though controversial, many clinical trials have been conducted to evaluate the efficacy of intravenous immunoglobulins (IVIG) in COVID-19 cases. Therefore, a systematic review and meta-analysis have been performed to evaluate the efficacy of IVIG in the treatment of COVID-19 patients.
Experimental approach: A systematic search was performed in electronic databases and preprint servers up to November 20, 2021. Since substantial heterogeneity was expected, a random-effects model was applied to pool effect size from included studies to calculate the standardized mean differences (SMDs) for the continuous variables and relative risks (RRs) for the dichotomous variable with 95% confidence intervals (CIs).
Findings/Results: Five randomized clinical trials and seven cohort studies were analyzed among the 12 eligible studies with a total of 2,156 patients. The pooled RR of mortality was 0.77 (CI 0.59-1.01, P-value = 0.06), and of mechanical ventilation was 1.50 (CI 0.29-7.83; P-value = 0.63) in the IVIG group compared with the standard care group. The pooled SMD of hospital length of stay was 0.84 (CI -0.43-2.11; P-value = 0.20) and of ICU length of stay was -0.07 (CI -0.92-0.78; P-value = 0.86) in the IVIG group compared with the standard care group.
Conclusion and implications: This meta-analysis found that the IVIG therapy was not statistically different from the standard care group. Mortality, ICU admission, mechanical ventilation, length of hospital stay, and length of ICU stay were not significantly improved among IVIG recipients. However, statistical indifference is not equal to clinical indifference. |
| first_indexed | 2024-03-12T22:08:52Z |
| format | Article |
| id | doaj.art-3f133559044840a3a01bb99c1ad98868 |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-03-12T22:08:52Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-3f133559044840a3a01bb99c1ad988682023-07-23T16:13:42ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142023-01-0118434635710.4103/1735-5362.378082Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysisBehzad FatemiSoheila RezaeiMohammad PeikanpourFarzaneh DastanAli SaffaeiBackground and purpose: Though controversial, many clinical trials have been conducted to evaluate the efficacy of intravenous immunoglobulins (IVIG) in COVID-19 cases. Therefore, a systematic review and meta-analysis have been performed to evaluate the efficacy of IVIG in the treatment of COVID-19 patients. Experimental approach: A systematic search was performed in electronic databases and preprint servers up to November 20, 2021. Since substantial heterogeneity was expected, a random-effects model was applied to pool effect size from included studies to calculate the standardized mean differences (SMDs) for the continuous variables and relative risks (RRs) for the dichotomous variable with 95% confidence intervals (CIs). Findings/Results: Five randomized clinical trials and seven cohort studies were analyzed among the 12 eligible studies with a total of 2,156 patients. The pooled RR of mortality was 0.77 (CI 0.59-1.01, P-value = 0.06), and of mechanical ventilation was 1.50 (CI 0.29-7.83; P-value = 0.63) in the IVIG group compared with the standard care group. The pooled SMD of hospital length of stay was 0.84 (CI -0.43-2.11; P-value = 0.20) and of ICU length of stay was -0.07 (CI -0.92-0.78; P-value = 0.86) in the IVIG group compared with the standard care group. Conclusion and implications: This meta-analysis found that the IVIG therapy was not statistically different from the standard care group. Mortality, ICU admission, mechanical ventilation, length of hospital stay, and length of ICU stay were not significantly improved among IVIG recipients. However, statistical indifference is not equal to clinical indifference.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=4;spage=346;epage=357;aulast=Fatemiclinical efficacy; intravenous immunoglobulin; meta-analysis; mortality rate; sars-cov-2 infection; systematic review |
| spellingShingle | Behzad Fatemi Soheila Rezaei Mohammad Peikanpour Farzaneh Dastan Ali Saffaei Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis Research in Pharmaceutical Sciences clinical efficacy; intravenous immunoglobulin; meta-analysis; mortality rate; sars-cov-2 infection; systematic review |
| title | Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis |
| title_full | Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis |
| title_fullStr | Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis |
| title_short | Efficacy of intravenous immunoglobulins (IVIG) in COVID-19 patients: a systematic review and meta-analysis |
| title_sort | efficacy of intravenous immunoglobulins ivig in covid 19 patients a systematic review and meta analysis |
| topic | clinical efficacy; intravenous immunoglobulin; meta-analysis; mortality rate; sars-cov-2 infection; systematic review |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=4;spage=346;epage=357;aulast=Fatemi |
| work_keys_str_mv | AT behzadfatemi efficacyofintravenousimmunoglobulinsivigincovid19patientsasystematicreviewandmetaanalysis AT soheilarezaei efficacyofintravenousimmunoglobulinsivigincovid19patientsasystematicreviewandmetaanalysis AT mohammadpeikanpour efficacyofintravenousimmunoglobulinsivigincovid19patientsasystematicreviewandmetaanalysis AT farzanehdastan efficacyofintravenousimmunoglobulinsivigincovid19patientsasystematicreviewandmetaanalysis AT alisaffaei efficacyofintravenousimmunoglobulinsivigincovid19patientsasystematicreviewandmetaanalysis |