Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?
G-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), wh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2345 |
| _version_ | 1797550085745147904 |
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| author | Jesús Cosín-Roger Dolores Ortiz-Masia Maria Dolores Barrachina Sara Calatayud |
| author_facet | Jesús Cosín-Roger Dolores Ortiz-Masia Maria Dolores Barrachina Sara Calatayud |
| author_sort | Jesús Cosín-Roger |
| collection | DOAJ |
| description | G-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), which can be selectively activated by metabolites. These metabolite sensing GPCRs control crucial processes, such as cell proliferation, differentiation, migration, and survival after their activation. In the present review, we will describe the main functions of these metabolite sensing GPCRs and shed light on the benefits of their potential use as possible pharmacological targets for cancer treatment. |
| first_indexed | 2024-03-10T15:23:28Z |
| format | Article |
| id | doaj.art-3f139c90de324a97bce88a93fd8c5925 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:23:28Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3f139c90de324a97bce88a93fd8c59252023-11-20T18:14:14ZengMDPI AGCells2073-44092020-10-01911234510.3390/cells9112345Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?Jesús Cosín-Roger0Dolores Ortiz-Masia1Maria Dolores Barrachina2Sara Calatayud3Hospital Dr. Peset, Fundación para la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO, 46017 Valencia, SpainDepartament of Medicine, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainDepartament of Pharmacology and CIBER, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainDepartament of Pharmacology and CIBER, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainG-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), which can be selectively activated by metabolites. These metabolite sensing GPCRs control crucial processes, such as cell proliferation, differentiation, migration, and survival after their activation. In the present review, we will describe the main functions of these metabolite sensing GPCRs and shed light on the benefits of their potential use as possible pharmacological targets for cancer treatment.https://www.mdpi.com/2073-4409/9/11/2345G-protein-coupled receptormetabolite sensing GPCRcancer |
| spellingShingle | Jesús Cosín-Roger Dolores Ortiz-Masia Maria Dolores Barrachina Sara Calatayud Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? Cells G-protein-coupled receptor metabolite sensing GPCR cancer |
| title | Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? |
| title_full | Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? |
| title_fullStr | Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? |
| title_full_unstemmed | Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? |
| title_short | Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment? |
| title_sort | metabolite sensing gpcrs promising therapeutic targets for cancer treatment |
| topic | G-protein-coupled receptor metabolite sensing GPCR cancer |
| url | https://www.mdpi.com/2073-4409/9/11/2345 |
| work_keys_str_mv | AT jesuscosinroger metabolitesensinggpcrspromisingtherapeutictargetsforcancertreatment AT doloresortizmasia metabolitesensinggpcrspromisingtherapeutictargetsforcancertreatment AT mariadoloresbarrachina metabolitesensinggpcrspromisingtherapeutictargetsforcancertreatment AT saracalatayud metabolitesensinggpcrspromisingtherapeutictargetsforcancertreatment |