GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia
<p>Abstract</p> <p>Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most of...
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | Biology Direct |
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| Online Access: | http://www.biology-direct.com/content/8/1/5 |
| _version_ | 1818126345484369920 |
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| author | Hegyi Hedi |
| author_facet | Hegyi Hedi |
| author_sort | Hegyi Hedi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.</p> <p>Reviewers</p> <p>This paper was reviewed by Sandor Pongor and Martijn Huynen.</p> |
| first_indexed | 2024-12-11T06:59:59Z |
| format | Article |
| id | doaj.art-3f1539abaeaf4602ad4b3d82d52a3e1b |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-11T06:59:59Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-3f1539abaeaf4602ad4b3d82d52a3e1b2022-12-22T01:16:39ZengBMCBiology Direct1745-61502013-02-0181510.1186/1745-6150-8-5GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophreniaHegyi Hedi<p>Abstract</p> <p>Schizophrenia is a complex disease with uncertain aetiology. We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1.</p> <p>Reviewers</p> <p>This paper was reviewed by Sandor Pongor and Martijn Huynen.</p>http://www.biology-direct.com/content/8/1/5SchizophreniaHuman endogenous retrovirusHERV-Wlong terminal repeatLTRGABAGABBR1GABA receptorEnhancerSilencer |
| spellingShingle | Hegyi Hedi GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia Biology Direct Schizophrenia Human endogenous retrovirus HERV-W long terminal repeat LTR GABA GABBR1 GABA receptor Enhancer Silencer |
| title | GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia |
| title_full | GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia |
| title_fullStr | GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia |
| title_full_unstemmed | GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia |
| title_short | GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia |
| title_sort | gabbr1 has a herv w ltr in its regulatory region a possible implication for schizophrenia |
| topic | Schizophrenia Human endogenous retrovirus HERV-W long terminal repeat LTR GABA GABBR1 GABA receptor Enhancer Silencer |
| url | http://www.biology-direct.com/content/8/1/5 |
| work_keys_str_mv | AT hegyihedi gabbr1hasahervwltrinitsregulatoryregionapossibleimplicationforschizophrenia |