NO-tryptophan: a new small molecule located in the rat brain
<p>A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10<sup>-9 </sup>M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the i...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2016-09-01
|
| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/2692 |
| _version_ | 1818145953829355520 |
|---|---|
| author | A. Mangas J. Yajeya N. González S. Duleu M. Geffard R. Coveñas |
| author_facet | A. Mangas J. Yajeya N. González S. Duleu M. Geffard R. Coveñas |
| author_sort | A. Mangas |
| collection | DOAJ |
| description | <p>A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10<sup>-9 </sup>M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the intermediate and dorsal parts of the lateral septal nucleus. No immunoreactive fibres were found in the rat brain. This work reports the first visualization and the morphological characteristics of cell bodies containing NO-W in the mammalian brain. The restricted distribution of NO-W in the rat brain suggests that this molecule could be involved in specific physiological mechanisms. </p> |
| first_indexed | 2024-12-11T12:11:39Z |
| format | Article |
| id | doaj.art-3f174eb261a643c3b6c8a19c3ac61f0e |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-11T12:11:39Z |
| publishDate | 2016-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-3f174eb261a643c3b6c8a19c3ac61f0e2022-12-22T01:07:46ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062016-09-0160310.4081/ejh.2016.26921522NO-tryptophan: a new small molecule located in the rat brainA. Mangas0J. Yajeya1N. González2S. Duleu3M. Geffard4R. Coveñas5Gemacbio - Institute for the Development of Research in Human Pathology and Therapeutic (IDRPHT) -University of SalamancaUniversity of SalamanacaGemacbioInstitute for the Development of Research in Human Pathology and Therapeutic (IDRPHT)Gemacbio - Institute for the Development of Research in Human Pathology and Therapeutic (IDRPHT)University of Salamanca<p>A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10<sup>-9 </sup>M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the intermediate and dorsal parts of the lateral septal nucleus. No immunoreactive fibres were found in the rat brain. This work reports the first visualization and the morphological characteristics of cell bodies containing NO-W in the mammalian brain. The restricted distribution of NO-W in the rat brain suggests that this molecule could be involved in specific physiological mechanisms. </p>http://www.ejh.it/index.php/ejh/article/view/2692Lateral septal nucleusseptummonoclonal antibodycell bodynitric oxideimmunohistochemistry. |
| spellingShingle | A. Mangas J. Yajeya N. González S. Duleu M. Geffard R. Coveñas NO-tryptophan: a new small molecule located in the rat brain European Journal of Histochemistry Lateral septal nucleus septum monoclonal antibody cell body nitric oxide immunohistochemistry. |
| title | NO-tryptophan: a new small molecule located in the rat brain |
| title_full | NO-tryptophan: a new small molecule located in the rat brain |
| title_fullStr | NO-tryptophan: a new small molecule located in the rat brain |
| title_full_unstemmed | NO-tryptophan: a new small molecule located in the rat brain |
| title_short | NO-tryptophan: a new small molecule located in the rat brain |
| title_sort | no tryptophan a new small molecule located in the rat brain |
| topic | Lateral septal nucleus septum monoclonal antibody cell body nitric oxide immunohistochemistry. |
| url | http://www.ejh.it/index.php/ejh/article/view/2692 |
| work_keys_str_mv | AT amangas notryptophananewsmallmoleculelocatedintheratbrain AT jyajeya notryptophananewsmallmoleculelocatedintheratbrain AT ngonzalez notryptophananewsmallmoleculelocatedintheratbrain AT sduleu notryptophananewsmallmoleculelocatedintheratbrain AT mgeffard notryptophananewsmallmoleculelocatedintheratbrain AT rcovenas notryptophananewsmallmoleculelocatedintheratbrain |