Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning
Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits. In brain physiology, highly dynamic microglial processes are facilitated to sense the surrounding environment and stimuli. Once the b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1284;epage=1290;aulast=Huo |
| _version_ | 1797231730982125568 |
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| author | Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong |
| author_facet | Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong |
| author_sort | Anran Huo |
| collection | DOAJ |
| description | Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits. In brain physiology, highly dynamic microglial processes are facilitated to sense the surrounding environment and stimuli. Once the brain switches its functional states, microglia are recruited to specific sites to exert their immune functions, including the release of cytokines and phagocytosis of cellular debris. The crosstalk of microglia between neurons, neural stem cells, endothelial cells, oligodendrocytes, and astrocytes contributes to their functions in synapse pruning, neurogenesis, vascularization, myelination, and blood-brain barrier permeability. In this review, we highlight the neuron-derived “find-me,” “eat-me,” and “don’t eat-me” molecular signals that drive microglia in response to changes in neuronal activity for synapse refinement during brain development. This review reveals the molecular mechanism of neuron-microglia interaction in synaptic pruning and presents novel ideas for the synaptic pruning of microglia in disease, thereby providing important clues for discovery of target drugs and development of nervous system disease treatment methods targeting synaptic dysfunction. |
| first_indexed | 2024-04-24T15:49:02Z |
| format | Article |
| id | doaj.art-3f189a507e7e499a85180368e207384b |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T15:49:02Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-3f189a507e7e499a85180368e207384b2024-04-01T13:05:59ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-011961284129010.4103/1673-5374.385854Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruningAnran HuoJiali WangQi LiMengqi LiYuwan QiQiao YinWeifeng LuoJijun ShiQifei CongMicroglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits. In brain physiology, highly dynamic microglial processes are facilitated to sense the surrounding environment and stimuli. Once the brain switches its functional states, microglia are recruited to specific sites to exert their immune functions, including the release of cytokines and phagocytosis of cellular debris. The crosstalk of microglia between neurons, neural stem cells, endothelial cells, oligodendrocytes, and astrocytes contributes to their functions in synapse pruning, neurogenesis, vascularization, myelination, and blood-brain barrier permeability. In this review, we highlight the neuron-derived “find-me,” “eat-me,” and “don’t eat-me” molecular signals that drive microglia in response to changes in neuronal activity for synapse refinement during brain development. This review reveals the molecular mechanism of neuron-microglia interaction in synaptic pruning and presents novel ideas for the synaptic pruning of microglia in disease, thereby providing important clues for discovery of target drugs and development of nervous system disease treatment methods targeting synaptic dysfunction.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1284;epage=1290;aulast=Huocomplement; immune signals; microglia; molecular signal; synapse elimination; synapse formation; synapse refinement; synaptic pruning |
| spellingShingle | Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning Neural Regeneration Research complement; immune signals; microglia; molecular signal; synapse elimination; synapse formation; synapse refinement; synaptic pruning |
| title | Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| title_full | Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| title_fullStr | Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| title_full_unstemmed | Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| title_short | Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| title_sort | molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning |
| topic | complement; immune signals; microglia; molecular signal; synapse elimination; synapse formation; synapse refinement; synaptic pruning |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1284;epage=1290;aulast=Huo |
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