Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells

Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells

Abstract Background The mechanisms of endocrine resistance are complex, and deregulation of several oncogenic signalling pathways has been proposed. We aimed to investigate the role of the EGFR and Src-mediated STAT3 signalling pathway in tamoxifen-resistant breast cancer cells. Methods The ER-posit...

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Bibliographic Details
Main Authors:	Seo Yun Moon, Heejin Lee, Seoree Kim, Ji Hyung Hong, Sang Hoon Chun, Hee Yeon Lee, Keunsoo Kang, Ho Shik Kim, Hye Sung Won, Yoon Ho Ko
Format:	Article
Language:	English
Published:	BMC 2021-08-01
Series:	BMC Cancer
Subjects:	Breast cancer Endocrine resistance Src Epidermal growth factor receptor Signal transducer and activator of transcription protein
Online Access:	https://doi.org/10.1186/s12885-021-08641-7

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