The role of CD47 in non-neoplastic diseases
CD47 is a 50 kDa five-spanning membrane receptor that plays a crucial role in multiple cellular processes, including myeloid cell activation, neutrophils transmigration, vascular remodeling, leukocyte adhesion and trans-endothelial migration. Recent studies have revealed that CD47 is a highly expres...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023101137 |
| _version_ | 1797383919107047424 |
|---|---|
| author | Chao Wang Ying Feng Deepali Patel Hongwei Xie Yaqing Lv Hai Zhao |
| author_facet | Chao Wang Ying Feng Deepali Patel Hongwei Xie Yaqing Lv Hai Zhao |
| author_sort | Chao Wang |
| collection | DOAJ |
| description | CD47 is a 50 kDa five-spanning membrane receptor that plays a crucial role in multiple cellular processes, including myeloid cell activation, neutrophils transmigration, vascular remodeling, leukocyte adhesion and trans-endothelial migration. Recent studies have revealed that CD47 is a highly expressed anti-phagocytic signal in several types of cancer, and therefore, blocking of CD47 has shown an effective therapeutic potential in cancer immunotherapy. In addition, CD47 has been found to be involved in a complex interplay with microglia and other types of cells, and increasing evidence indicates that CD47 can be targeted as part of immune modulatory strategies for non-neoplastic diseases as well. In this review, we focus on CD47 and its role in non-neoplastic diseases, including neurological disorders, atherosclerosis and autoimmune diseases. In addition, we discuss the major challenges and potential remedies associated with CD47-SIRPα-based immunotherapies. |
| first_indexed | 2024-03-08T21:28:00Z |
| format | Article |
| id | doaj.art-3f1b19a58e8c4ce683c1fbd13e3b358c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T21:28:00Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3f1b19a58e8c4ce683c1fbd13e3b358c2023-12-21T07:35:07ZengElsevierHeliyon2405-84402023-12-01912e22905The role of CD47 in non-neoplastic diseasesChao Wang0Ying Feng1Deepali Patel2Hongwei Xie3Yaqing Lv4Hai Zhao5Department of Neurosurgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaDepartment of Emergency, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaSchool of Medicine, Qingdao University, No. 308 Ningxia Road, Qingdao, Shandong, 266071, ChinaDepartment of Neurosurgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaDepartment of Outpatient, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, ChinaDepartment of Neurosurgery, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong, 266005, China; Corresponding author.CD47 is a 50 kDa five-spanning membrane receptor that plays a crucial role in multiple cellular processes, including myeloid cell activation, neutrophils transmigration, vascular remodeling, leukocyte adhesion and trans-endothelial migration. Recent studies have revealed that CD47 is a highly expressed anti-phagocytic signal in several types of cancer, and therefore, blocking of CD47 has shown an effective therapeutic potential in cancer immunotherapy. In addition, CD47 has been found to be involved in a complex interplay with microglia and other types of cells, and increasing evidence indicates that CD47 can be targeted as part of immune modulatory strategies for non-neoplastic diseases as well. In this review, we focus on CD47 and its role in non-neoplastic diseases, including neurological disorders, atherosclerosis and autoimmune diseases. In addition, we discuss the major challenges and potential remedies associated with CD47-SIRPα-based immunotherapies.http://www.sciencedirect.com/science/article/pii/S2405844023101137CD47SIRPαImmune modulationImmunotherapiesAtherosclerosisNeurological disorders |
| spellingShingle | Chao Wang Ying Feng Deepali Patel Hongwei Xie Yaqing Lv Hai Zhao The role of CD47 in non-neoplastic diseases Heliyon CD47 SIRPα Immune modulation Immunotherapies Atherosclerosis Neurological disorders |
| title | The role of CD47 in non-neoplastic diseases |
| title_full | The role of CD47 in non-neoplastic diseases |
| title_fullStr | The role of CD47 in non-neoplastic diseases |
| title_full_unstemmed | The role of CD47 in non-neoplastic diseases |
| title_short | The role of CD47 in non-neoplastic diseases |
| title_sort | role of cd47 in non neoplastic diseases |
| topic | CD47 SIRPα Immune modulation Immunotherapies Atherosclerosis Neurological disorders |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023101137 |
| work_keys_str_mv | AT chaowang theroleofcd47innonneoplasticdiseases AT yingfeng theroleofcd47innonneoplasticdiseases AT deepalipatel theroleofcd47innonneoplasticdiseases AT hongweixie theroleofcd47innonneoplasticdiseases AT yaqinglv theroleofcd47innonneoplasticdiseases AT haizhao theroleofcd47innonneoplasticdiseases AT chaowang roleofcd47innonneoplasticdiseases AT yingfeng roleofcd47innonneoplasticdiseases AT deepalipatel roleofcd47innonneoplasticdiseases AT hongweixie roleofcd47innonneoplasticdiseases AT yaqinglv roleofcd47innonneoplasticdiseases AT haizhao roleofcd47innonneoplasticdiseases |