In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins
Immunoglobulin-like (Ig-like) fold domains are abundant on the surface of bacteria, where they are required for cell-to-cell recognition, adhesion, biofilm formation, and conjugative transfer. Fibrillar adhesins are proteins with Ig-like fold(s) that have filamentous structures at the cell surface,...
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MDPI AG
2022-02-01
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Online Access: | https://www.mdpi.com/2072-6651/14/2/133 |
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author | Dan Wang Haoran Wang |
author_facet | Dan Wang Haoran Wang |
author_sort | Dan Wang |
collection | DOAJ |
description | Immunoglobulin-like (Ig-like) fold domains are abundant on the surface of bacteria, where they are required for cell-to-cell recognition, adhesion, biofilm formation, and conjugative transfer. Fibrillar adhesins are proteins with Ig-like fold(s) that have filamentous structures at the cell surface, being thinner and more flexible than pili. While the roles of fibrillar adhesins have been proposed in bacteria overall, their characterization in <i>Vibrio parahaemolyticus</i> has not been established and, therefore, understanding about fibrillar adhesins remain limited in <i>V</i><i>. parahaemolyticus</i>. This in silico analysis can aid in the systematic identification of Ig-like-folded and fibrillar adhesin-like proteins in <i>V. parahaemolyticus</i>, opening new avenues for disease prevention by interfering in microbial interaction between <i>V. parahaemolyticus</i> and the host. |
first_indexed | 2024-03-09T20:55:18Z |
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institution | Directory Open Access Journal |
issn | 2072-6651 |
language | English |
last_indexed | 2024-03-09T20:55:18Z |
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series | Toxins |
spelling | doaj.art-3f1b240405e442c3a9aaa29c60f8f10b2023-11-23T22:21:54ZengMDPI AGToxins2072-66512022-02-0114213310.3390/toxins14020133In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar AdhesinsDan Wang0Haoran Wang1School of Food and Advanced Technology, Massey University, Palmerston North 4410, New ZealandSchool of Medicine, Jiangsu University, Zhenjiang 212000, ChinaImmunoglobulin-like (Ig-like) fold domains are abundant on the surface of bacteria, where they are required for cell-to-cell recognition, adhesion, biofilm formation, and conjugative transfer. Fibrillar adhesins are proteins with Ig-like fold(s) that have filamentous structures at the cell surface, being thinner and more flexible than pili. While the roles of fibrillar adhesins have been proposed in bacteria overall, their characterization in <i>Vibrio parahaemolyticus</i> has not been established and, therefore, understanding about fibrillar adhesins remain limited in <i>V</i><i>. parahaemolyticus</i>. This in silico analysis can aid in the systematic identification of Ig-like-folded and fibrillar adhesin-like proteins in <i>V. parahaemolyticus</i>, opening new avenues for disease prevention by interfering in microbial interaction between <i>V. parahaemolyticus</i> and the host.https://www.mdpi.com/2072-6651/14/2/133fibrillar adhesinhomologueprotein interfacedrug target |
spellingShingle | Dan Wang Haoran Wang In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins Toxins fibrillar adhesin homologue protein interface drug target |
title | In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins |
title_full | In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins |
title_fullStr | In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins |
title_full_unstemmed | In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins |
title_short | In Silico Approach Gives Insights into Ig-like Fold Containing Proteins in <i>Vibrio parahaemolyticus</i>: A Focus on the Fibrillar Adhesins |
title_sort | in silico approach gives insights into ig like fold containing proteins in i vibrio parahaemolyticus i a focus on the fibrillar adhesins |
topic | fibrillar adhesin homologue protein interface drug target |
url | https://www.mdpi.com/2072-6651/14/2/133 |
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