The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck
Background: Delays in starting postoperative radiotherapy (PORT) have been established as negative predictors for clinical outcomes in head and neck squamous cell carcinomas (HNSCC). Our study aimed to examine the effect of delays during PORT, and the impact of national holidays in Canada, a publicl...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Clinical and Translational Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630823000939 |
| _version_ | 1827855527414071296 |
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| author | Michael S. Kim Margaret Sheridan Murali Rajaraman Helmut Hollenhorst Amanda Caissie Ashraf Mahmoud-Ahmed Nathan Lamond Stephanie Snow Martin Corsten S. Mark Taylor Jonathan R.B. Trites Matthew H. Rigby Martin Bullock Derek Wilke |
| author_facet | Michael S. Kim Margaret Sheridan Murali Rajaraman Helmut Hollenhorst Amanda Caissie Ashraf Mahmoud-Ahmed Nathan Lamond Stephanie Snow Martin Corsten S. Mark Taylor Jonathan R.B. Trites Matthew H. Rigby Martin Bullock Derek Wilke |
| author_sort | Michael S. Kim |
| collection | DOAJ |
| description | Background: Delays in starting postoperative radiotherapy (PORT) have been established as negative predictors for clinical outcomes in head and neck squamous cell carcinomas (HNSCC). Our study aimed to examine the effect of delays during PORT, and the impact of national holidays in Canada, a publicly funded system, on oncologic outcomes such as Overall Survival (OS) and Local Recurrence (LR). Methods: The provincial cancer registry was queried to obtain demographic, pathologic, and outcomes data from cancer patients treated for all squamous cell carcinomas of the head and neck region treated between January 1, 2007 and November 30, 2019. All extracted information was cross-referenced and supplemented by chart review of patient electronic medical records. Extracted data were analyzed for OS and LR, in the context of Canadian national holidays causing delays during PORT. Results: 1433 patients treated for HNSCCs were identified, of whom 338 were treated curatively with surgery followed by PORT. 68.6% of patients experienced at least one day of interruption during treatments due to holidays. LR was 15.4% and OS was 59.6% at 5 years. Treatment interruptions by holidays were predictive of local recurrence (HR, 2.38; 95% CI 1.17–4.83; p = 0.017). Patients that developed early recurrence prior to PORT had very poor oncologic outcomes. Conclusion: Our findings were consistent with previously published studies in limiting the interval between surgery and PORT. We identified the novel finding of paired holidays as a significant predictor in determining LR, suggesting the importance of modifying RT delivery schedules and timing. |
| first_indexed | 2024-03-12T11:52:17Z |
| format | Article |
| id | doaj.art-3f1b2ec01379443ca05de3531fd002f3 |
| institution | Directory Open Access Journal |
| issn | 2405-6308 |
| language | English |
| last_indexed | 2024-03-12T11:52:17Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj.art-3f1b2ec01379443ca05de3531fd002f32023-08-31T05:03:25ZengElsevierClinical and Translational Radiation Oncology2405-63082023-09-0142100668The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neckMichael S. Kim0Margaret Sheridan1Murali Rajaraman2Helmut Hollenhorst3Amanda Caissie4Ashraf Mahmoud-Ahmed5Nathan Lamond6Stephanie Snow7Martin Corsten8S. Mark Taylor9Jonathan R.B. Trites10Matthew H. Rigby11Martin Bullock12Derek Wilke13Department of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, Halifax, Canada; Corresponding authors at: Department of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, 5820 University Avenue, Halifax, NS B3H 2Y9, Canada.Division of Medical Oncology – Department of Medicine, Dalhousie University, Halifax, CanadaDepartment of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, Halifax, CanadaDepartment of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, Halifax, CanadaDepartment of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, Halifax, CanadaDepartment of Radiation Oncology, Cape Breton Cancer Centre, Dalhousie University, Halifax, CanadaDivision of Medical Oncology – Department of Medicine, Dalhousie University, Halifax, CanadaDivision of Medical Oncology – Department of Medicine, Dalhousie University, Halifax, CanadaDivision of Otolaryngology – Head and Neck Surgery, Dalhousie University, Halifax, CanadaDepartment of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, CanadaDepartment of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, CanadaDepartment of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, CanadaDepartment of Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, CanadaDepartment of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, Halifax, Canada; Corresponding authors at: Department of Radiation Oncology, Nova Scotia Cancer Centre, Dalhousie University, 5820 University Avenue, Halifax, NS B3H 2Y9, Canada.Background: Delays in starting postoperative radiotherapy (PORT) have been established as negative predictors for clinical outcomes in head and neck squamous cell carcinomas (HNSCC). Our study aimed to examine the effect of delays during PORT, and the impact of national holidays in Canada, a publicly funded system, on oncologic outcomes such as Overall Survival (OS) and Local Recurrence (LR). Methods: The provincial cancer registry was queried to obtain demographic, pathologic, and outcomes data from cancer patients treated for all squamous cell carcinomas of the head and neck region treated between January 1, 2007 and November 30, 2019. All extracted information was cross-referenced and supplemented by chart review of patient electronic medical records. Extracted data were analyzed for OS and LR, in the context of Canadian national holidays causing delays during PORT. Results: 1433 patients treated for HNSCCs were identified, of whom 338 were treated curatively with surgery followed by PORT. 68.6% of patients experienced at least one day of interruption during treatments due to holidays. LR was 15.4% and OS was 59.6% at 5 years. Treatment interruptions by holidays were predictive of local recurrence (HR, 2.38; 95% CI 1.17–4.83; p = 0.017). Patients that developed early recurrence prior to PORT had very poor oncologic outcomes. Conclusion: Our findings were consistent with previously published studies in limiting the interval between surgery and PORT. We identified the novel finding of paired holidays as a significant predictor in determining LR, suggesting the importance of modifying RT delivery schedules and timing.http://www.sciencedirect.com/science/article/pii/S2405630823000939Head and neck cancerClinical oncologyRadiotherapyPublic health systemsResource managementAccelerated radiotherapy |
| spellingShingle | Michael S. Kim Margaret Sheridan Murali Rajaraman Helmut Hollenhorst Amanda Caissie Ashraf Mahmoud-Ahmed Nathan Lamond Stephanie Snow Martin Corsten S. Mark Taylor Jonathan R.B. Trites Matthew H. Rigby Martin Bullock Derek Wilke The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck Clinical and Translational Radiation Oncology Head and neck cancer Clinical oncology Radiotherapy Public health systems Resource management Accelerated radiotherapy |
| title | The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| title_full | The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| title_fullStr | The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| title_full_unstemmed | The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| title_short | The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| title_sort | impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck |
| topic | Head and neck cancer Clinical oncology Radiotherapy Public health systems Resource management Accelerated radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630823000939 |
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