Structure and Biological Activity of Ergostane-Type Steroids from Fungi
Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2103 |
| _version_ | 1797438442750083072 |
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| author | Vladimir N. Zhabinskii Pavel Drasar Vladimir A. Khripach |
| author_facet | Vladimir N. Zhabinskii Pavel Drasar Vladimir A. Khripach |
| author_sort | Vladimir N. Zhabinskii |
| collection | DOAJ |
| description | Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility. |
| first_indexed | 2024-03-09T11:36:50Z |
| format | Article |
| id | doaj.art-3f1b9bb1fa91402e899d4b30083e0f69 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:36:50Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3f1b9bb1fa91402e899d4b30083e0f692023-11-30T23:39:36ZengMDPI AGMolecules1420-30492022-03-01277210310.3390/molecules27072103Structure and Biological Activity of Ergostane-Type Steroids from FungiVladimir N. Zhabinskii0Pavel Drasar1Vladimir A. Khripach2Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str., 5/2, 220141 Minsk, BelarusDepartment of Chemistry of Natural Compounds, University of Chemistry and Technology, Technicka 5, CZ-166 28 Prague, Czech RepublicInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str., 5/2, 220141 Minsk, BelarusMushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.https://www.mdpi.com/1420-3049/27/7/2103ergosterolergosteroidsfungimushroomsanticancerantiviral |
| spellingShingle | Vladimir N. Zhabinskii Pavel Drasar Vladimir A. Khripach Structure and Biological Activity of Ergostane-Type Steroids from Fungi Molecules ergosterol ergosteroids fungi mushrooms anticancer antiviral |
| title | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
| title_full | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
| title_fullStr | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
| title_full_unstemmed | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
| title_short | Structure and Biological Activity of Ergostane-Type Steroids from Fungi |
| title_sort | structure and biological activity of ergostane type steroids from fungi |
| topic | ergosterol ergosteroids fungi mushrooms anticancer antiviral |
| url | https://www.mdpi.com/1420-3049/27/7/2103 |
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