Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review
Objectives:: To evaluate the reported literature on the use of stem cells or growth factors for post extraction treatment of the alveolar bone. Material and Methods: A NCBI PubMed and PubMed Central databases search was conducted between September 2010 and August 2018, to identify animal or clini...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Stilus Optimus
2019-09-01
|
| Series: | eJournal of Oral Maxillofacial Research |
| Subjects: | |
| Online Access: | https://www.ejomr.org/JOMR/archives/2019/3/e7/v10n3e7ht.htm |
| _version_ | 1811312228701306880 |
|---|---|
| author | Mindaugas Pranskunas Pablo Galindo-Moreno Miguel Padial-Molina |
| author_facet | Mindaugas Pranskunas Pablo Galindo-Moreno Miguel Padial-Molina |
| author_sort | Mindaugas Pranskunas |
| collection | DOAJ |
| description | Objectives:: To evaluate the reported literature on the use of stem cells or growth factors for post extraction treatment of the alveolar bone.
Material and Methods: A NCBI PubMed and PubMed Central databases search was conducted between September 2010 and August 2018, to identify animal or clinical studies reporting the clinical, radiographical and/or histological outcomes of socket preservation techniques after applying mesenchymal stem cells or growth factors. Only studies published in English language in the last 10 years were included in the study
Results: Eleven studies were identified fulfilling the inclusion criteria. They evaluate a total of 386 post extraction sockets. The main tested materials identified in the current review were bone morphogenetic protein-2 - 3 studies and mesenchymal stem cells - 3 studies. Other comparators were bone morphogenetic protein-9, platelet-derived growth factor-BB homodimers and bone marrow. Overall evaluation indicate positive results for all test groups showing differences in final socket width between 0.64 and 1.28 mm favouring the test groups. Histologically, no particular differences are detected between test and control groups. Most of the studies present low risk of bias.
Conclusions: In general, the use of mesenchymal stem cells or bioactive osteogenic molecules favours bone regeneration after tooth extraction, as evaluated clinically, radiographically and histologically. However, specific differences that support particular recommendations are still unclear in light of the current published evidence. Future studies should include the standardization of the mesenchymal stem cells selection and purification as well as dosage and delivery methods of bioactive molecules. |
| first_indexed | 2024-04-13T10:33:44Z |
| format | Article |
| id | doaj.art-3f1e3446ce3a4407a270fa3eae19c3eb |
| institution | Directory Open Access Journal |
| issn | 2029-283X |
| language | English |
| last_indexed | 2024-04-13T10:33:44Z |
| publishDate | 2019-09-01 |
| publisher | Stilus Optimus |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj.art-3f1e3446ce3a4407a270fa3eae19c3eb2022-12-22T02:50:07ZengStilus OptimuseJournal of Oral Maxillofacial Research2029-283X2019-09-01103e710.5037/jomr.2019.10307Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic ReviewMindaugas PranskunasPablo Galindo-MorenoMiguel Padial-MolinaObjectives:: To evaluate the reported literature on the use of stem cells or growth factors for post extraction treatment of the alveolar bone. Material and Methods: A NCBI PubMed and PubMed Central databases search was conducted between September 2010 and August 2018, to identify animal or clinical studies reporting the clinical, radiographical and/or histological outcomes of socket preservation techniques after applying mesenchymal stem cells or growth factors. Only studies published in English language in the last 10 years were included in the study Results: Eleven studies were identified fulfilling the inclusion criteria. They evaluate a total of 386 post extraction sockets. The main tested materials identified in the current review were bone morphogenetic protein-2 - 3 studies and mesenchymal stem cells - 3 studies. Other comparators were bone morphogenetic protein-9, platelet-derived growth factor-BB homodimers and bone marrow. Overall evaluation indicate positive results for all test groups showing differences in final socket width between 0.64 and 1.28 mm favouring the test groups. Histologically, no particular differences are detected between test and control groups. Most of the studies present low risk of bias. Conclusions: In general, the use of mesenchymal stem cells or bioactive osteogenic molecules favours bone regeneration after tooth extraction, as evaluated clinically, radiographically and histologically. However, specific differences that support particular recommendations are still unclear in light of the current published evidence. Future studies should include the standardization of the mesenchymal stem cells selection and purification as well as dosage and delivery methods of bioactive molecules.https://www.ejomr.org/JOMR/archives/2019/3/e7/v10n3e7ht.htmalveolar bone atrophyalveolar bone graftingbone remodelingmesenchymal stem cellsstem cell transplantationtransforming growth factors |
| spellingShingle | Mindaugas Pranskunas Pablo Galindo-Moreno Miguel Padial-Molina Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review eJournal of Oral Maxillofacial Research alveolar bone atrophy alveolar bone grafting bone remodeling mesenchymal stem cells stem cell transplantation transforming growth factors |
| title | Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review |
| title_full | Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review |
| title_fullStr | Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review |
| title_full_unstemmed | Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review |
| title_short | Extraction Socket Preservation Using Growth Factors and Stem Cells: a Systematic Review |
| title_sort | extraction socket preservation using growth factors and stem cells a systematic review |
| topic | alveolar bone atrophy alveolar bone grafting bone remodeling mesenchymal stem cells stem cell transplantation transforming growth factors |
| url | https://www.ejomr.org/JOMR/archives/2019/3/e7/v10n3e7ht.htm |
| work_keys_str_mv | AT mindaugaspranskunas extractionsocketpreservationusinggrowthfactorsandstemcellsasystematicreview AT pablogalindomoreno extractionsocketpreservationusinggrowthfactorsandstemcellsasystematicreview AT miguelpadialmolina extractionsocketpreservationusinggrowthfactorsandstemcellsasystematicreview |