Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2646 |
| _version_ | 1797454957556793344 |
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| author | Patrick Affeldt Felix Carlo Koehler Karl August Brensing Martin Gies Eva Platen Vivien Adam Linus Butt Franziska Grundmann Eva Heger Steffen Hinrichs Nils Kalisch Simon Oehm Gertrud Steger Maike Wirtz Thomas Benzing Dirk Stippel Florian Klein Christine Kurschat Roman-Ulrich Müller Veronica Di Cristanziano |
| author_facet | Patrick Affeldt Felix Carlo Koehler Karl August Brensing Martin Gies Eva Platen Vivien Adam Linus Butt Franziska Grundmann Eva Heger Steffen Hinrichs Nils Kalisch Simon Oehm Gertrud Steger Maike Wirtz Thomas Benzing Dirk Stippel Florian Klein Christine Kurschat Roman-Ulrich Müller Veronica Di Cristanziano |
| author_sort | Patrick Affeldt |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate against BA.1 was significant lower. Concerning KTX recipients, humoral and cellular immune responses after a third vaccination were still highly impaired. This calls for modified omicron-targeting vaccines. |
| first_indexed | 2024-03-09T15:44:36Z |
| format | Article |
| id | doaj.art-3f1f2d366f7f4a4bb437841c1714572a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:44:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3f1f2d366f7f4a4bb437841c1714572a2023-11-24T18:37:06ZengMDPI AGViruses1999-49152022-11-011412264610.3390/v14122646Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant RecipientsPatrick Affeldt0Felix Carlo Koehler1Karl August Brensing2Martin Gies3Eva Platen4Vivien Adam5Linus Butt6Franziska Grundmann7Eva Heger8Steffen Hinrichs9Nils Kalisch10Simon Oehm11Gertrud Steger12Maike Wirtz13Thomas Benzing14Dirk Stippel15Florian Klein16Christine Kurschat17Roman-Ulrich Müller18Veronica Di Cristanziano19Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyNierenzentrum Bonn, 53175 Bonn, GermanyKfH-Nierenzentrum Köln-Longerich, 50737 Cologne, GermanyNierenzentrum Eifel, 53894 Mechernich, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, GermanyInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyInstitute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, GermanySevere acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate against BA.1 was significant lower. Concerning KTX recipients, humoral and cellular immune responses after a third vaccination were still highly impaired. This calls for modified omicron-targeting vaccines.https://www.mdpi.com/1999-4915/14/12/2646BA.1dialysisimmunosuppressionneutralizationprotectionsurrogate |
| spellingShingle | Patrick Affeldt Felix Carlo Koehler Karl August Brensing Martin Gies Eva Platen Vivien Adam Linus Butt Franziska Grundmann Eva Heger Steffen Hinrichs Nils Kalisch Simon Oehm Gertrud Steger Maike Wirtz Thomas Benzing Dirk Stippel Florian Klein Christine Kurschat Roman-Ulrich Müller Veronica Di Cristanziano Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients Viruses BA.1 dialysis immunosuppression neutralization protection surrogate |
| title | Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients |
| title_full | Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients |
| title_fullStr | Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients |
| title_full_unstemmed | Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients |
| title_short | Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients |
| title_sort | immune response to third and fourth covid 19 vaccination in hemodialysis patients and kidney transplant recipients |
| topic | BA.1 dialysis immunosuppression neutralization protection surrogate |
| url | https://www.mdpi.com/1999-4915/14/12/2646 |
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