Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country
Background: Medullary thyroid carcinoma (MTC) is a rare type of thyroid cancer that occasionally occurs as part of MEN2A. The universal treatment of MTC is total thyroidectomy with central lymph node dissection. For disease progression, carcinoembryonic antigen (CEA) and calcitonin (CTN) need to be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=1;spage=68;epage=72;aulast=Khan |
| _version_ | 1818234189093273600 |
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| author | Sajjad A Khan Abdul Aziz Umer A Esbhani Muhammad Q Masood |
| author_facet | Sajjad A Khan Abdul Aziz Umer A Esbhani Muhammad Q Masood |
| author_sort | Sajjad A Khan |
| collection | DOAJ |
| description | Background: Medullary thyroid carcinoma (MTC) is a rare type of thyroid cancer that occasionally occurs as part of MEN2A. The universal treatment of MTC is total thyroidectomy with central lymph node dissection. For disease progression, carcinoembryonic antigen (CEA) and calcitonin (CTN) need to be followed. Our aim was to study the presence and patterns of the above-mentioned characteristics of MTC in our population. Methodology: This retrospective study was conducted in a tertiary care hospital of Pakistan in which data of thirty-two medullary thyroid cancer patients over the past 20 years were reviewed and analysed after fulfilment of inclusion criteria. Their clinical, pathological, biochemical and treatment modalities were recorded through a retrospective review of their medical record files. Results: The mean age of patients was 42.88 ± 2.67 years in our study, with a male-to-female ratio of 2:1. Patients with sporadic MTC were 68.8%, while 31.2% were familial. The rates of metastasis were highest in bones followed by lungs and liver. Total thyroidectomy was performed in 26 (81.2%) patients and among those chemotherapy and XRT were performed in one and two patients, respectively. Histologically, the mean tumour size was 7.62 ± 3.64 cm. Median pre-surgery calcitonin was 5756 pg/ml that decreased to 29.3 pg/ml post-surgery. Median pre-surgery CEA level was 246.5 ng/ml that decreased to 6.39 ng/ml post-surgery. Two patients were RET positive. Conclusion: MTC usually presents in the fourth decade of life with male predominance and mostly sporadic occurrence. Total thyroidectomy with subsequent serial calcitonin and CEA levels thereafter are the mainstay of treatment and follow-up. |
| first_indexed | 2024-12-12T11:34:07Z |
| format | Article |
| id | doaj.art-3f1f8a422fe249ef934d9226bd8fa3ec |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-12T11:34:07Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-3f1f8a422fe249ef934d9226bd8fa3ec2022-12-22T00:25:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102022-01-01261687210.4103/ijem.ijem_474_21Medullary thyroid cancer: An experience from a tertiary care hospital of a developing countrySajjad A KhanAbdul AzizUmer A EsbhaniMuhammad Q MasoodBackground: Medullary thyroid carcinoma (MTC) is a rare type of thyroid cancer that occasionally occurs as part of MEN2A. The universal treatment of MTC is total thyroidectomy with central lymph node dissection. For disease progression, carcinoembryonic antigen (CEA) and calcitonin (CTN) need to be followed. Our aim was to study the presence and patterns of the above-mentioned characteristics of MTC in our population. Methodology: This retrospective study was conducted in a tertiary care hospital of Pakistan in which data of thirty-two medullary thyroid cancer patients over the past 20 years were reviewed and analysed after fulfilment of inclusion criteria. Their clinical, pathological, biochemical and treatment modalities were recorded through a retrospective review of their medical record files. Results: The mean age of patients was 42.88 ± 2.67 years in our study, with a male-to-female ratio of 2:1. Patients with sporadic MTC were 68.8%, while 31.2% were familial. The rates of metastasis were highest in bones followed by lungs and liver. Total thyroidectomy was performed in 26 (81.2%) patients and among those chemotherapy and XRT were performed in one and two patients, respectively. Histologically, the mean tumour size was 7.62 ± 3.64 cm. Median pre-surgery calcitonin was 5756 pg/ml that decreased to 29.3 pg/ml post-surgery. Median pre-surgery CEA level was 246.5 ng/ml that decreased to 6.39 ng/ml post-surgery. Two patients were RET positive. Conclusion: MTC usually presents in the fourth decade of life with male predominance and mostly sporadic occurrence. Total thyroidectomy with subsequent serial calcitonin and CEA levels thereafter are the mainstay of treatment and follow-up.http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=1;spage=68;epage=72;aulast=Khanclinicopathological characteristicsdeveloping countrymedullary thyroid cancer |
| spellingShingle | Sajjad A Khan Abdul Aziz Umer A Esbhani Muhammad Q Masood Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country Indian Journal of Endocrinology and Metabolism clinicopathological characteristics developing country medullary thyroid cancer |
| title | Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country |
| title_full | Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country |
| title_fullStr | Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country |
| title_full_unstemmed | Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country |
| title_short | Medullary thyroid cancer: An experience from a tertiary care hospital of a developing country |
| title_sort | medullary thyroid cancer an experience from a tertiary care hospital of a developing country |
| topic | clinicopathological characteristics developing country medullary thyroid cancer |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=1;spage=68;epage=72;aulast=Khan |
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