Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis
<i>Background:</i> High-grade neuroendocrine carcinoma (NEC) is a rare and aggressive variant of bladder cancer. Considering its rarity, its therapeutic management is challenging and not standardized. <i>Methods:</i> We analyzed data extracted from the Surveillance, Epidemiol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/8/461 |
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| author | Veronica Mollica Francesco Massari Elisa Andrini Matteo Rosellini Andrea Marchetti Giacomo Nuvola Elisa Tassinari Giuseppe Lamberti Davide Campana |
| author_facet | Veronica Mollica Francesco Massari Elisa Andrini Matteo Rosellini Andrea Marchetti Giacomo Nuvola Elisa Tassinari Giuseppe Lamberti Davide Campana |
| author_sort | Veronica Mollica |
| collection | DOAJ |
| description | <i>Background:</i> High-grade neuroendocrine carcinoma (NEC) is a rare and aggressive variant of bladder cancer. Considering its rarity, its therapeutic management is challenging and not standardized. <i>Methods:</i> We analyzed data extracted from the Surveillance, Epidemiology, and End Results (SEER) registry to evaluate prognostic factors for high-grade NEC of the bladder. <i>Results:</i> We extracted data on 1134 patients: 77.6% were small cell NEC, 14.6% were NEC, 5.5% were mixed neuro-endocrine non-neuroendocrine neoplasia, and 2.3% were large cell NEC. The stage at diagnosis was localized for 45% of patients, lymph nodal disease (N+M0) for 9.2% of patients, and metastatic disease for 26.1% of patients. The median overall survival (OS) was 12 months. Multivariate analysis detected that factors associated with worse OS were age being >72 years old (HR 1.94), lymph nodal involvement (HR 2.01), metastatic disease (HR 2.04), and the size of the primary tumor being >44.5 mm (HR 1.80). In the N0M0 populations, the size of the primary tumor being <44.5 mm, age being <72 years old, and major surgery were independently associated with a lower risk of death. In the N+M0 group, the size of the primary lesion was the only factor to retain an association with OS. <i>Conclusions:</i> Our SEER database analysis evidenced prognostic factors for high-grade NEC of the bladder that are of pivotal relevance to guide treatment and the decision-making process. |
| first_indexed | 2024-03-09T13:35:53Z |
| format | Article |
| id | doaj.art-3f1fb0cf0cfc4dce97c2fb59a7832fec |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:35:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-3f1fb0cf0cfc4dce97c2fb59a7832fec2023-11-30T21:11:47ZengMDPI AGCurrent Oncology1198-00521718-77292022-08-012985846585410.3390/curroncol29080461Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database AnalysisVeronica Mollica0Francesco Massari1Elisa Andrini2Matteo Rosellini3Andrea Marchetti4Giacomo Nuvola5Elisa Tassinari6Giuseppe Lamberti7Davide Campana8Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy<i>Background:</i> High-grade neuroendocrine carcinoma (NEC) is a rare and aggressive variant of bladder cancer. Considering its rarity, its therapeutic management is challenging and not standardized. <i>Methods:</i> We analyzed data extracted from the Surveillance, Epidemiology, and End Results (SEER) registry to evaluate prognostic factors for high-grade NEC of the bladder. <i>Results:</i> We extracted data on 1134 patients: 77.6% were small cell NEC, 14.6% were NEC, 5.5% were mixed neuro-endocrine non-neuroendocrine neoplasia, and 2.3% were large cell NEC. The stage at diagnosis was localized for 45% of patients, lymph nodal disease (N+M0) for 9.2% of patients, and metastatic disease for 26.1% of patients. The median overall survival (OS) was 12 months. Multivariate analysis detected that factors associated with worse OS were age being >72 years old (HR 1.94), lymph nodal involvement (HR 2.01), metastatic disease (HR 2.04), and the size of the primary tumor being >44.5 mm (HR 1.80). In the N0M0 populations, the size of the primary tumor being <44.5 mm, age being <72 years old, and major surgery were independently associated with a lower risk of death. In the N+M0 group, the size of the primary lesion was the only factor to retain an association with OS. <i>Conclusions:</i> Our SEER database analysis evidenced prognostic factors for high-grade NEC of the bladder that are of pivotal relevance to guide treatment and the decision-making process.https://www.mdpi.com/1718-7729/29/8/461bladder carcinomaLCNECMiNENNECNENneuroendocrine |
| spellingShingle | Veronica Mollica Francesco Massari Elisa Andrini Matteo Rosellini Andrea Marchetti Giacomo Nuvola Elisa Tassinari Giuseppe Lamberti Davide Campana Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis Current Oncology bladder carcinoma LCNEC MiNEN NEC NEN neuroendocrine |
| title | Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis |
| title_full | Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis |
| title_fullStr | Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis |
| title_full_unstemmed | Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis |
| title_short | Prognostic Factors of Survival for High-Grade Neuroendocrine Neoplasia of the Bladder: A SEER Database Analysis |
| title_sort | prognostic factors of survival for high grade neuroendocrine neoplasia of the bladder a seer database analysis |
| topic | bladder carcinoma LCNEC MiNEN NEC NEN neuroendocrine |
| url | https://www.mdpi.com/1718-7729/29/8/461 |
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