Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11

Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11

Abstract Glioblastoma (GBM) cells require large amounts of iron for tumor growth and progression, which makes these cells vulnerable to destruction via ferroptosis induction. Mitochondria are critical for iron metabolism and ferroptosis. Sirtuin-3 (SIRT3) is a deacetylase found in mitochondria that...

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Bibliographic Details
Main Authors: Xiaohe Li, Wenlong Zhang, Zhengcao Xing, Shuming Hu, Geqiang Zhang, Tiange Wang, Tianshi Wang, Qiuju Fan, Guoqiang Chen, Jinke Cheng, Xianguo Jiang, Rong Cai
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06558-0

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