Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome.
Crohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4160179?pdf=render |
| _version_ | 1818290355497336832 |
|---|---|
| author | Sonia Pellissier Cécile Dantzer Laurie Mondillon Candice Trocme Anne-Sophie Gauchez Véronique Ducros Nicolas Mathieu Bertrand Toussaint Alicia Fournier Frédéric Canini Bruno Bonaz |
| author_facet | Sonia Pellissier Cécile Dantzer Laurie Mondillon Candice Trocme Anne-Sophie Gauchez Véronique Ducros Nicolas Mathieu Bertrand Toussaint Alicia Fournier Frédéric Canini Bruno Bonaz |
| author_sort | Sonia Pellissier |
| collection | DOAJ |
| description | Crohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects (controls). The study was performed in 73 subjects (26 controls, 21 CD in remission and 26 IBS patients). The day prior to the experiment, salivary cortisol was measured at 8:00 AM and 10:00 PM. The day of the experiment, subjects completed questionnaires for anxiety (STAI) and depressive symptoms (CES-D). After 30 min of rest, ECG was recorded for heart rate variability (HRV) analysis. Plasma cortisol, epinephrine, norepinephrine, TNF-alpha and IL-6 were measured in blood samples taken at the end of ECG recording. Compared with controls, CD and IBS patients had higher scores of state-anxiety and depressive symptomatology. A subgroup classification based on HRV-normalized high frequency band (HFnu) as a marker of vagal tone, showed that control subjects with high vagal tone had significantly lower evening salivary cortisol levels than subjects with low vagal tone. Such an effect was not observed in CD and IBS patients. Moreover, an inverse association (r = -0.48; p<0.05) was observed between the vagal tone and TNF-alpha level in CD patients exclusively. In contrast, in IBS patients, vagal tone was inversely correlated with plasma epinephrine (r = -0.39; p<0.05). No relationship was observed between vagal tone and IL-6, norepinephrine or negative affects (anxiety and depressive symptomatology) in any group. In conclusion, these data argue for an imbalance between the hypothalamus-pituitary-adrenal axis and the vagal tone in CD and IBS patients. Furthermore, they highlight the specific homeostatic link between vagal tone and TNF-alpha in CD and epinephrine in IBS and argue for the relevance of vagus nerve reinforcement interventions in those diseases. |
| first_indexed | 2024-12-13T02:26:51Z |
| format | Article |
| id | doaj.art-3f232d9108ce42de99219e76449559a1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:26:51Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3f232d9108ce42de99219e76449559a12022-12-22T00:02:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10532810.1371/journal.pone.0105328Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome.Sonia PellissierCécile DantzerLaurie MondillonCandice TrocmeAnne-Sophie GauchezVéronique DucrosNicolas MathieuBertrand ToussaintAlicia FournierFrédéric CaniniBruno BonazCrohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects (controls). The study was performed in 73 subjects (26 controls, 21 CD in remission and 26 IBS patients). The day prior to the experiment, salivary cortisol was measured at 8:00 AM and 10:00 PM. The day of the experiment, subjects completed questionnaires for anxiety (STAI) and depressive symptoms (CES-D). After 30 min of rest, ECG was recorded for heart rate variability (HRV) analysis. Plasma cortisol, epinephrine, norepinephrine, TNF-alpha and IL-6 were measured in blood samples taken at the end of ECG recording. Compared with controls, CD and IBS patients had higher scores of state-anxiety and depressive symptomatology. A subgroup classification based on HRV-normalized high frequency band (HFnu) as a marker of vagal tone, showed that control subjects with high vagal tone had significantly lower evening salivary cortisol levels than subjects with low vagal tone. Such an effect was not observed in CD and IBS patients. Moreover, an inverse association (r = -0.48; p<0.05) was observed between the vagal tone and TNF-alpha level in CD patients exclusively. In contrast, in IBS patients, vagal tone was inversely correlated with plasma epinephrine (r = -0.39; p<0.05). No relationship was observed between vagal tone and IL-6, norepinephrine or negative affects (anxiety and depressive symptomatology) in any group. In conclusion, these data argue for an imbalance between the hypothalamus-pituitary-adrenal axis and the vagal tone in CD and IBS patients. Furthermore, they highlight the specific homeostatic link between vagal tone and TNF-alpha in CD and epinephrine in IBS and argue for the relevance of vagus nerve reinforcement interventions in those diseases.http://europepmc.org/articles/PMC4160179?pdf=render |
| spellingShingle | Sonia Pellissier Cécile Dantzer Laurie Mondillon Candice Trocme Anne-Sophie Gauchez Véronique Ducros Nicolas Mathieu Bertrand Toussaint Alicia Fournier Frédéric Canini Bruno Bonaz Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. PLoS ONE |
| title | Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. |
| title_full | Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. |
| title_fullStr | Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. |
| title_full_unstemmed | Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. |
| title_short | Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome. |
| title_sort | relationship between vagal tone cortisol tnf alpha epinephrine and negative affects in crohn s disease and irritable bowel syndrome |
| url | http://europepmc.org/articles/PMC4160179?pdf=render |
| work_keys_str_mv | AT soniapellissier relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT ceciledantzer relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT lauriemondillon relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT candicetrocme relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT annesophiegauchez relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT veroniqueducros relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT nicolasmathieu relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT bertrandtoussaint relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT aliciafournier relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT fredericcanini relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome AT brunobonaz relationshipbetweenvagaltonecortisoltnfalphaepinephrineandnegativeaffectsincrohnsdiseaseandirritablebowelsyndrome |