Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Abstract Background A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence suggests that adenosine deaminases acting on RNA 1 (ADAR1) correlates to oxidative stress that is a crucial factor of HCC pathogenesis. The present study investig...

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Bibliographic Details
Main Authors: Houhong Wang, Xiaoyu Wei, Lu Liu, Junfeng Zhang, Heng Li
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Experimental Hematology & Oncology
Subjects:
ADAR1
Hepatocellular carcinoma
Oxidative stress
Survival
Keap1/Nrf2
Reactive oxygen species
Online Access:https://doi.org/10.1186/s40164-024-00494-7

Internet

https://doi.org/10.1186/s40164-024-00494-7

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