Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress

Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress

Background: Endoplasmic reticulum stress (ERS) has been recently suggested to be activated in the major depressive disorder (MDD). However, whether ERS is a potential therapeutic target for MDD is largely unknown. Here we attempted to assess the preventive effect of metoprolol (MET), N-acetylcystein...

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Bibliographic Details
Main Authors: Lixia Yang, Lei Zheng, Yan Wan, Zhenghong Chen, Peifan Li, Yiming Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder
endoplasmic reticulum stress
apoptosis
metoprolol
N-acetylcysteine
escitalopram
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00696/full

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