Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats
Background & aim: Diabetes is a chronic disease which induces a rise in inflammatory response and endothelial disorders. The aim of present study was to review the response of ICAM-1, VCAM- 1 and CRP serum level to high and moderate endurance trainings in diabetic rats. Methods: In the presen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2016-11-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-612-2&slc_lang=en&sid=1 |
| _version_ | 1811199974394822656 |
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| author | S Farsi Azarbayjani MA SA Hosseini P Pirei |
| author_facet | S Farsi Azarbayjani MA SA Hosseini P Pirei |
| author_sort | S Farsi |
| collection | DOAJ |
| description | Background & aim: Diabetes is a chronic disease which induces a rise in inflammatory response and endothelial disorders. The aim of present study was to review the response of ICAM-1, VCAM- 1 and CRP serum level to high and moderate endurance trainings in diabetic rats.
Methods: In the present experimental research, thirty-two diabetic male sprague dawley rats were selected and based on their blood glucose, they were divided into four groups of eight: (1) diabetes sacrifice first week, (2) diabetes sacrifice last week, (3) moderate intensity endurance training and (4) high intensity endurance training and for review the effects of diabetes induction 16 healthy rats divided in two groups of healthy sacrifice first week and healthy sacrifice last week. Rats of high and moderate intensity endurance trainings ran on treadmill for eight weeks, three sessions per week and 60 minutes with intensity of 10- 17 and 17- 28 meter per minute. To analyze the data, the Kolmogorov-Smirnov tests, ANOVA with Tukey test was used.
Results: Results indicated that induction of diabetes resulted in a significant increase in ICAM-1 (p=0.001), VCAM- 1 (p=0.001) and CRP (p=0.001) respectivly. Eight weeks moderate and high intensity endurance training showed a significant reduction on ICAM-1 (p=0.001), VCAM- 1 (p=0.003) and CRP (p=0.001) and such reduction on ICAM-1 (p=0.04), VCAM- 1 (p=0.04) and CRP (p=0.001) respectively. Also moderate and high intensity endurance trainings had equal effects on ICAM-1 (p=0.53), VCAM- 1 (p=0.90) and CRP (p=0.99) on diabetic rats.
Conclusion: Moderate and high intensity endurance trainings had equal effects on reduction of ICAM-1, VCAM- 1and CRP on diabetic rats. |
| first_indexed | 2024-04-12T01:56:51Z |
| format | Article |
| id | doaj.art-3f259cec15064c51bc313fb37d86c00b |
| institution | Directory Open Access Journal |
| issn | 1728-6514 1728-6506 |
| language | fas |
| last_indexed | 2024-04-12T01:56:51Z |
| publishDate | 2016-11-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-3f259cec15064c51bc313fb37d86c00b2022-12-22T03:52:47ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65141728-65062016-11-01218757771Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic RatsS Farsi0Azarbayjani MA1SA Hosseini2P Pirei3 Department of Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Department of Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Department of Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Department of Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Background & aim: Diabetes is a chronic disease which induces a rise in inflammatory response and endothelial disorders. The aim of present study was to review the response of ICAM-1, VCAM- 1 and CRP serum level to high and moderate endurance trainings in diabetic rats. Methods: In the present experimental research, thirty-two diabetic male sprague dawley rats were selected and based on their blood glucose, they were divided into four groups of eight: (1) diabetes sacrifice first week, (2) diabetes sacrifice last week, (3) moderate intensity endurance training and (4) high intensity endurance training and for review the effects of diabetes induction 16 healthy rats divided in two groups of healthy sacrifice first week and healthy sacrifice last week. Rats of high and moderate intensity endurance trainings ran on treadmill for eight weeks, three sessions per week and 60 minutes with intensity of 10- 17 and 17- 28 meter per minute. To analyze the data, the Kolmogorov-Smirnov tests, ANOVA with Tukey test was used. Results: Results indicated that induction of diabetes resulted in a significant increase in ICAM-1 (p=0.001), VCAM- 1 (p=0.001) and CRP (p=0.001) respectivly. Eight weeks moderate and high intensity endurance training showed a significant reduction on ICAM-1 (p=0.001), VCAM- 1 (p=0.003) and CRP (p=0.001) and such reduction on ICAM-1 (p=0.04), VCAM- 1 (p=0.04) and CRP (p=0.001) respectively. Also moderate and high intensity endurance trainings had equal effects on ICAM-1 (p=0.53), VCAM- 1 (p=0.90) and CRP (p=0.99) on diabetic rats. Conclusion: Moderate and high intensity endurance trainings had equal effects on reduction of ICAM-1, VCAM- 1and CRP on diabetic rats.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-612-2&slc_lang=en&sid=1: intensity endurance training ICAM-1 VCAM- 1 CRP |
| spellingShingle | S Farsi Azarbayjani MA SA Hosseini P Pirei Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats Armaghane Danesh Bimonthly Journal : intensity endurance training ICAM-1 VCAM- 1 CRP |
| title | Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats |
| title_full | Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats |
| title_fullStr | Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats |
| title_full_unstemmed | Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats |
| title_short | Response of Serum Levels of ICAM-1 VCAM- 1and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats |
| title_sort | response of serum levels of icam 1 vcam 1and crp to high and moderate endurance trainings in sprague dawley male diabetic rats |
| topic | : intensity endurance training ICAM-1 VCAM- 1 CRP |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-612-2&slc_lang=en&sid=1 |
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