ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS
Objective: to reveal neurogenic mechanisms in the pathogenesis of chronic pain syndrome in rheumatoid arthritis (RA) and knee osteoarthritis (OA) in order to develop individualized pharmacotherapy.Subjects and methods. One hundred and eighty-three patients with RA and 80 with knee OA were examined....
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2014-12-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2008 |
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| author | E. S. Filatova E. F. Turovskaya L. I. Alekseeva Sh. F. Erdes E. G. Filatova |
| author_facet | E. S. Filatova E. F. Turovskaya L. I. Alekseeva Sh. F. Erdes E. G. Filatova |
| author_sort | E. S. Filatova |
| collection | DOAJ |
| description | Objective: to reveal neurogenic mechanisms in the pathogenesis of chronic pain syndrome in rheumatoid arthritis (RA) and knee osteoarthritis (OA) in order to develop individualized pharmacotherapy.Subjects and methods. One hundred and eighty-three patients with RA and 80 with knee OA were examined. By using the neuropathic pain diagnostic questionnaire (DN4), all the patients were divided into 2 groups with and without a neuropathic pain component (NPC).Results. NPC was found in 43% of the patients with RA and it was connected with involvement of the peripheral somatosensory system. In RA, NPC was common in older patients with longer disease duration, higher X-ray stage, and severe functional insufficiency. 30% of patients with knee OA also had NPC, however the signs of nervous system involvement were absent. In OA, NPC was associated with hyperalgesia, higher pain intensity, more marked joint dysfunction on the WOMAC, and anxiety.Discussion. This investigation revealed a mixed pattern of chronic pain syndrome in patients with RA and knee OA; some patients were found to have a NPC in the presence of predominantly a nociceptive component |
| first_indexed | 2024-04-09T22:24:56Z |
| format | Article |
| id | doaj.art-3f2644ee01114396bf24a96518084166 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:24:56Z |
| publishDate | 2014-12-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-3f2644ee01114396bf24a965180841662023-03-22T13:45:50ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922014-12-0152663163510.14412/1995-4484-2014-631-6351927ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITISE. S. Filatova0E. F. Turovskaya1L. I. Alekseeva2Sh. F. Erdes3E. G. Filatova4V.A. Nasonova Research Institute of Rheumatology, Moscow, RussiaV.A. Nasonova Research Institute of Rheumatology, Moscow, Russia I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, RussiaV.A. Nasonova Research Institute of Rheumatology, Moscow, RussiaV.A. Nasonova Research Institute of Rheumatology, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, RussiaObjective: to reveal neurogenic mechanisms in the pathogenesis of chronic pain syndrome in rheumatoid arthritis (RA) and knee osteoarthritis (OA) in order to develop individualized pharmacotherapy.Subjects and methods. One hundred and eighty-three patients with RA and 80 with knee OA were examined. By using the neuropathic pain diagnostic questionnaire (DN4), all the patients were divided into 2 groups with and without a neuropathic pain component (NPC).Results. NPC was found in 43% of the patients with RA and it was connected with involvement of the peripheral somatosensory system. In RA, NPC was common in older patients with longer disease duration, higher X-ray stage, and severe functional insufficiency. 30% of patients with knee OA also had NPC, however the signs of nervous system involvement were absent. In OA, NPC was associated with hyperalgesia, higher pain intensity, more marked joint dysfunction on the WOMAC, and anxiety.Discussion. This investigation revealed a mixed pattern of chronic pain syndrome in patients with RA and knee OA; some patients were found to have a NPC in the presence of predominantly a nociceptive componenthttps://rsp.mediar-press.net/rsp/article/view/2008rheumatoid arthritisknee osteoarthritisneuropathic pain componentchronic pain syndrome |
| spellingShingle | E. S. Filatova E. F. Turovskaya L. I. Alekseeva Sh. F. Erdes E. G. Filatova ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS Научно-практическая ревматология rheumatoid arthritis knee osteoarthritis neuropathic pain component chronic pain syndrome |
| title | ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS |
| title_full | ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS |
| title_fullStr | ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS |
| title_full_unstemmed | ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS |
| title_short | ANALYSIS OF THE PATHOGENETIC MECHANISMS OF CHRONIC JOINT PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND KNEE OSTEOARTHRITIS |
| title_sort | analysis of the pathogenetic mechanisms of chronic joint pain in patients with rheumatoid arthritis and knee osteoarthritis |
| topic | rheumatoid arthritis knee osteoarthritis neuropathic pain component chronic pain syndrome |
| url | https://rsp.mediar-press.net/rsp/article/view/2008 |
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