The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors
The habenula is a complex nucleus composed of lateral and medial subnuclei, which connect between the limbic forebrain and midbrain. Over the past few years, the lateral habenula has received considerable attention because of its potential roles in cognition and in the pathogenesis of various psychi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00100/full |
| _version_ | 1818844575243960320 |
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| author | Hyun Woo Lee Soo Hyun Yang Jin Yong Kim Hyun Kim |
| author_facet | Hyun Woo Lee Soo Hyun Yang Jin Yong Kim Hyun Kim |
| author_sort | Hyun Woo Lee |
| collection | DOAJ |
| description | The habenula is a complex nucleus composed of lateral and medial subnuclei, which connect between the limbic forebrain and midbrain. Over the past few years, the lateral habenula has received considerable attention because of its potential roles in cognition and in the pathogenesis of various psychiatric disorders. Unlike extensively studied lateral habenula, anatomically and histologically distinct medial habenula remains largely understudied. The medial habenula can be further subdivided into a dorsal region containing excitatory neurons that express the tachykinin neuropeptide substance P and a ventral region containing dense cholinergic neurons. Although the medial habenula is the source of one of the major cholinergic pathways in the brain, relatively few studies have been conducted to understand its roles. Recently, however, the medial habenula cholinergic system has attracted more attention because of its potential to provide therapeutic targets for the treatment of nicotine withdrawal symptoms, drug addiction, and various mood disorders. Here, we discuss the role of the medial habenula cholinergic system in brain function. |
| first_indexed | 2024-12-19T05:15:56Z |
| format | Article |
| id | doaj.art-3f299564cbdc4fdc9c38c40ddb1862c4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-19T05:15:56Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-3f299564cbdc4fdc9c38c40ddb1862c42022-12-21T20:34:40ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-02-011010.3389/fpsyt.2019.00100437937The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated BehaviorsHyun Woo LeeSoo Hyun YangJin Yong KimHyun KimThe habenula is a complex nucleus composed of lateral and medial subnuclei, which connect between the limbic forebrain and midbrain. Over the past few years, the lateral habenula has received considerable attention because of its potential roles in cognition and in the pathogenesis of various psychiatric disorders. Unlike extensively studied lateral habenula, anatomically and histologically distinct medial habenula remains largely understudied. The medial habenula can be further subdivided into a dorsal region containing excitatory neurons that express the tachykinin neuropeptide substance P and a ventral region containing dense cholinergic neurons. Although the medial habenula is the source of one of the major cholinergic pathways in the brain, relatively few studies have been conducted to understand its roles. Recently, however, the medial habenula cholinergic system has attracted more attention because of its potential to provide therapeutic targets for the treatment of nicotine withdrawal symptoms, drug addiction, and various mood disorders. Here, we discuss the role of the medial habenula cholinergic system in brain function.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00100/fullhabenulacholinergic systemnicotine addiction and withdrawaldrug addictionfeardepression |
| spellingShingle | Hyun Woo Lee Soo Hyun Yang Jin Yong Kim Hyun Kim The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors Frontiers in Psychiatry habenula cholinergic system nicotine addiction and withdrawal drug addiction fear depression |
| title | The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors |
| title_full | The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors |
| title_fullStr | The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors |
| title_full_unstemmed | The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors |
| title_short | The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors |
| title_sort | role of the medial habenula cholinergic system in addiction and emotion associated behaviors |
| topic | habenula cholinergic system nicotine addiction and withdrawal drug addiction fear depression |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00100/full |
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