Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway

Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway

Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the cyclic adenosine 3′,5′-monophosphate (cAMP) signaling pathway, leading to ovarian reserve decline in mice. A chronic stress mo...

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Bibliographic Details
Main Authors: Yiwen Jiang, Jing Xu, Chengqiu Tao, Yunying Lin, Xiaoqi Lin, Ke Li, Qiyu Liu, Hexige Saiyin, Shuanggang Hu, Guangxin Yao, Yun Sun, Feng Zhang, Yu Kang, Congjian Xu, Ling Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
Subjects:
cAMP pathways
chronic stress
CUBIC method
meiotic arrest failure
ovarian reserve decline
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1177061/full

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