Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis
Abstract Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by a malodorous discharge and irritation. The imbalance of the vaginal microbiota plays a key role in the development of BV. It has been demonstrated that Gardnerella vaginalis (GV), a facultative anaerobic bacillus, is in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28957-7 |
| _version_ | 1797865104141713408 |
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| author | Marika Lanza Sarah Adriana Scuderi Anna Paola Capra Giovanna Casili Alessia Filippone Michela Campolo Salvatore Cuzzocrea Emanuela Esposito Irene Paterniti |
| author_facet | Marika Lanza Sarah Adriana Scuderi Anna Paola Capra Giovanna Casili Alessia Filippone Michela Campolo Salvatore Cuzzocrea Emanuela Esposito Irene Paterniti |
| author_sort | Marika Lanza |
| collection | DOAJ |
| description | Abstract Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by a malodorous discharge and irritation. The imbalance of the vaginal microbiota plays a key role in the development of BV. It has been demonstrated that Gardnerella vaginalis (GV), a facultative anaerobic bacillus, is involved in BV. Due to the rising number of antimicrobial-resistant species, recurrence of BV is becoming more frequent in women; thus, alternative treatments to antibiotics are needed. Natural substances have recently shown a great efficacy for the treatment of vaginal dysbiosis. Thus, this study aimed to investigate the beneficial effect of a product containing pea protein (PP), grape seed extract (GS) and lactic acid (LA) in an in vivo model of Gardnerella vaginalis-induced vaginosis by intravaginal administration of GV suspension (1 × 106 CFU/20 µL saline). Our results demonstrated that the product containing PP, GS and LA significantly reduced GV proliferation. More specifically, it significantly preserved tissue architecture and reduced neutrophil infiltration, inflammatory markers and sialidase activity when used both as a pre- or a post-treatment. Moreover, the product displayed strong bioadhesive properties. Therefore, our data suggested that the product containing PP, GS and LA could be used as alternative preventive or curative treatment for the management of BV. |
| first_indexed | 2024-04-09T23:02:42Z |
| format | Article |
| id | doaj.art-3f2ad00415304c9e8ef5988cd504de42 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:02:42Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3f2ad00415304c9e8ef5988cd504de422023-03-22T10:51:53ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-28957-7Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosisMarika Lanza0Sarah Adriana Scuderi1Anna Paola Capra2Giovanna Casili3Alessia Filippone4Michela Campolo5Salvatore Cuzzocrea6Emanuela Esposito7Irene Paterniti8Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaAbstract Bacterial vaginosis (BV) is a common vaginal dysbiosis characterized by a malodorous discharge and irritation. The imbalance of the vaginal microbiota plays a key role in the development of BV. It has been demonstrated that Gardnerella vaginalis (GV), a facultative anaerobic bacillus, is involved in BV. Due to the rising number of antimicrobial-resistant species, recurrence of BV is becoming more frequent in women; thus, alternative treatments to antibiotics are needed. Natural substances have recently shown a great efficacy for the treatment of vaginal dysbiosis. Thus, this study aimed to investigate the beneficial effect of a product containing pea protein (PP), grape seed extract (GS) and lactic acid (LA) in an in vivo model of Gardnerella vaginalis-induced vaginosis by intravaginal administration of GV suspension (1 × 106 CFU/20 µL saline). Our results demonstrated that the product containing PP, GS and LA significantly reduced GV proliferation. More specifically, it significantly preserved tissue architecture and reduced neutrophil infiltration, inflammatory markers and sialidase activity when used both as a pre- or a post-treatment. Moreover, the product displayed strong bioadhesive properties. Therefore, our data suggested that the product containing PP, GS and LA could be used as alternative preventive or curative treatment for the management of BV.https://doi.org/10.1038/s41598-023-28957-7 |
| spellingShingle | Marika Lanza Sarah Adriana Scuderi Anna Paola Capra Giovanna Casili Alessia Filippone Michela Campolo Salvatore Cuzzocrea Emanuela Esposito Irene Paterniti Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis Scientific Reports |
| title | Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| title_full | Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| title_fullStr | Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| title_full_unstemmed | Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| title_short | Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| title_sort | effect of a combination of pea protein grape seed extract and lactic acid in an in vivo model of bacterial vaginosis |
| url | https://doi.org/10.1038/s41598-023-28957-7 |
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