CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT
Parijoto (Medinilla speciosa Reinw. ex Blum) fruit is known to have pharmacological activity as cholesterol lowering levels. Its activity needs to be increased with nanoparticle system so that the active substance can bind 100% to the action target. This study aims to determine the formation of nano...
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| Format: | Article |
| Language: | English |
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Universitas Sanata Dharma
2020-11-01
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| Series: | Jurnal Farmasi Sains dan Komunitas |
| Subjects: | |
| Online Access: | https://e-journal.usd.ac.id/index.php/JFSK/article/view/2017 |
| _version_ | 1797785717355577344 |
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| author | Fania Putri Luhurningtyas Rissa Laila Vifta Nur Syarohmawati Mahardika Adhi Candra |
| author_facet | Fania Putri Luhurningtyas Rissa Laila Vifta Nur Syarohmawati Mahardika Adhi Candra |
| author_sort | Fania Putri Luhurningtyas |
| collection | DOAJ |
| description | Parijoto (Medinilla speciosa Reinw. ex Blum) fruit is known to have pharmacological activity as cholesterol lowering levels. Its activity needs to be increased with nanoparticle system so that the active substance can bind 100% to the action target. This study aims to determine the formation of nanoparticles from parijoto fruit (NEBP) and activity test as a decrease in cholesterol levels. The formation of nanoparticles used variations of concentration and volume of chitosan and NaTPP. Anti-cholesterol testing is based on the amount of free cholesterol in the sample that reacted with Lieberman-Burchard into complex green compounds. The best formation of NEBP was 0.2% chitosan, 0.1% NaTPP and volume ratio 5:1. The particle size showed an average size of 269.3 nm (10-1000 nm). The result of the percent transmittance and polydispersity index were 99,379 (close to 100%) and 0.378 (PDI 0.5). The functional group-specific of NEBP was OH, N-H, PO3. The morphology was round and non-uniform particles. NEBP can decrease 50% cholesterol levels with a smaller EC50 value was 89.08 compared to the extract (EC50 259.98 ppm). Nanoparticles of parijoto fruit is a potential candidate for anti-cholesterol drug. |
| first_indexed | 2024-03-13T00:58:52Z |
| format | Article |
| id | doaj.art-3f30722b391442abbef3dac35d1566da |
| institution | Directory Open Access Journal |
| issn | 1693-5683 2527-7146 |
| language | English |
| last_indexed | 2024-03-13T00:58:52Z |
| publishDate | 2020-11-01 |
| publisher | Universitas Sanata Dharma |
| record_format | Article |
| series | Jurnal Farmasi Sains dan Komunitas |
| spelling | doaj.art-3f30722b391442abbef3dac35d1566da2023-07-06T14:02:20ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462020-11-0117210211110.24071/jpsc.0020171806CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACTFania Putri Luhurningtyas0Rissa Laila Vifta1Nur Syarohmawati2Mahardika Adhi Candra3Program Studi S1 Farmasi, Universitas Ngudi WaluyoProgram Studi S1 Farmasi, Universitas Ngudi WaluyoProgram Studi S1 Farmasi, Universitas Ngudi WaluyoProgram Studi S1 Farmasi, Universitas Ngudi WaluyoParijoto (Medinilla speciosa Reinw. ex Blum) fruit is known to have pharmacological activity as cholesterol lowering levels. Its activity needs to be increased with nanoparticle system so that the active substance can bind 100% to the action target. This study aims to determine the formation of nanoparticles from parijoto fruit (NEBP) and activity test as a decrease in cholesterol levels. The formation of nanoparticles used variations of concentration and volume of chitosan and NaTPP. Anti-cholesterol testing is based on the amount of free cholesterol in the sample that reacted with Lieberman-Burchard into complex green compounds. The best formation of NEBP was 0.2% chitosan, 0.1% NaTPP and volume ratio 5:1. The particle size showed an average size of 269.3 nm (10-1000 nm). The result of the percent transmittance and polydispersity index were 99,379 (close to 100%) and 0.378 (PDI 0.5). The functional group-specific of NEBP was OH, N-H, PO3. The morphology was round and non-uniform particles. NEBP can decrease 50% cholesterol levels with a smaller EC50 value was 89.08 compared to the extract (EC50 259.98 ppm). Nanoparticles of parijoto fruit is a potential candidate for anti-cholesterol drug.https://e-journal.usd.ac.id/index.php/JFSK/article/view/2017anti-cholesterolfruitmedinilla speciosa reinw. ex blumnanoparticles. |
| spellingShingle | Fania Putri Luhurningtyas Rissa Laila Vifta Nur Syarohmawati Mahardika Adhi Candra CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT Jurnal Farmasi Sains dan Komunitas anti-cholesterol fruit medinilla speciosa reinw. ex blum nanoparticles. |
| title | CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT |
| title_full | CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT |
| title_fullStr | CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT |
| title_full_unstemmed | CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT |
| title_short | CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT |
| title_sort | cholesterol lowering effect of chitosan nanoparticles using parijoto fruits extract |
| topic | anti-cholesterol fruit medinilla speciosa reinw. ex blum nanoparticles. |
| url | https://e-journal.usd.ac.id/index.php/JFSK/article/view/2017 |
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