Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases
Background/Objectives: Lymphomatoid papulosis (LyP) is a cutaneous CD30+ lymphoproliferative disorder characterized by recurrent, self-healing lesions with a chronic clinical course. Approximately 10–20% of the patients have lymphomas, including mycosis fungoides (MF). LyP in association with MF is...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-06-01
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| Series: | Dermatologica Sinica |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S102781171300089X |
| _version_ | 1818501605724520448 |
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| author | Chien-Hun Huang Chao-Kai Hsu Julia Yu-Yun Lee |
| author_facet | Chien-Hun Huang Chao-Kai Hsu Julia Yu-Yun Lee |
| author_sort | Chien-Hun Huang |
| collection | DOAJ |
| description | Background/Objectives: Lymphomatoid papulosis (LyP) is a cutaneous CD30+ lymphoproliferative disorder characterized by recurrent, self-healing lesions with a chronic clinical course. Approximately 10–20% of the patients have lymphomas, including mycosis fungoides (MF). LyP in association with MF is not well documented in Taiwan. We aimed to describe the clinicopathologic characteristics of LyP with MF in a Taiwanese case series of LyP.
Methods: A retrospective clinicopathologic study was performed on cases of LyP with MF diagnosed in our Department during the period 1990–2012. The diagnosis of LyP and MF were based on their characteristic clinical and pathologic features as well as correlation with the clinical course of the specific skin lesions.
Results: A total of 24 cases of LyP (10 males and 14 females, age 18–63 years, mean 40.4 years) were included. Multiple biopsies were often done in individual patients during the clinical course to establish the diagnosis of LyP and MF. LyP was further classified pathologically as type A (n = 16), B (n = 3), C (n = 3), and mixed type with A&B (n = 1) and A&C (n = 1). Five cases (21%) also had MF; two had juvenile-onset LyP and three had juvenile-onset MF (one with hypopigmented MF, one with hyperpigmented MF, two with CD8+ LyP, and two with CD8+ MF). In the case of juvenile-onset hypopigmented CD8+ MF, the patient developed CD8+ LyP 25 years after the onset of MF and died of aggressive epidermotropic CD8+ lymphoma involving the skin and lung.
Conclusion: MF occurred in five of the 24 cases (21%) in the present series of LyP. These five cases had several unusual clinical and pathologic features, including subtle or uncommon skin manifestation of MF and more frequent juvenile-onset and CD8 phenotype of LyP and/or MF lesions. Long-term follow-up and repeated biopsy of selected skin lesions are necessary for correct diagnosis and proper treatment of both diseases. |
| first_indexed | 2024-12-10T20:58:36Z |
| format | Article |
| id | doaj.art-3f30de6365964864b9a71cef6e1d5a0d |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-10T20:58:36Z |
| publishDate | 2014-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-3f30de6365964864b9a71cef6e1d5a0d2022-12-22T01:33:53ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172014-06-01322758110.1016/j.dsi.2013.09.012Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese casesChien-Hun Huang0Chao-Kai Hsu1Julia Yu-Yun Lee2Department of Dermatology, National Cheng Kung University Medical College and Hospital, Tainan, TaiwanDepartment of Dermatology, National Cheng Kung University Medical College and Hospital, Tainan, TaiwanDepartment of Dermatology, National Cheng Kung University Medical College and Hospital, Tainan, TaiwanBackground/Objectives: Lymphomatoid papulosis (LyP) is a cutaneous CD30+ lymphoproliferative disorder characterized by recurrent, self-healing lesions with a chronic clinical course. Approximately 10–20% of the patients have lymphomas, including mycosis fungoides (MF). LyP in association with MF is not well documented in Taiwan. We aimed to describe the clinicopathologic characteristics of LyP with MF in a Taiwanese case series of LyP. Methods: A retrospective clinicopathologic study was performed on cases of LyP with MF diagnosed in our Department during the period 1990–2012. The diagnosis of LyP and MF were based on their characteristic clinical and pathologic features as well as correlation with the clinical course of the specific skin lesions. Results: A total of 24 cases of LyP (10 males and 14 females, age 18–63 years, mean 40.4 years) were included. Multiple biopsies were often done in individual patients during the clinical course to establish the diagnosis of LyP and MF. LyP was further classified pathologically as type A (n = 16), B (n = 3), C (n = 3), and mixed type with A&B (n = 1) and A&C (n = 1). Five cases (21%) also had MF; two had juvenile-onset LyP and three had juvenile-onset MF (one with hypopigmented MF, one with hyperpigmented MF, two with CD8+ LyP, and two with CD8+ MF). In the case of juvenile-onset hypopigmented CD8+ MF, the patient developed CD8+ LyP 25 years after the onset of MF and died of aggressive epidermotropic CD8+ lymphoma involving the skin and lung. Conclusion: MF occurred in five of the 24 cases (21%) in the present series of LyP. These five cases had several unusual clinical and pathologic features, including subtle or uncommon skin manifestation of MF and more frequent juvenile-onset and CD8 phenotype of LyP and/or MF lesions. Long-term follow-up and repeated biopsy of selected skin lesions are necessary for correct diagnosis and proper treatment of both diseases.http://www.sciencedirect.com/science/article/pii/S102781171300089XCD8+ lymphomahypopigmentedjuvenile-onsetlymphomatoid papulosismycosis fungoides |
| spellingShingle | Chien-Hun Huang Chao-Kai Hsu Julia Yu-Yun Lee Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases Dermatologica Sinica CD8+ lymphoma hypopigmented juvenile-onset lymphomatoid papulosis mycosis fungoides |
| title | Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases |
| title_full | Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases |
| title_fullStr | Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases |
| title_full_unstemmed | Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases |
| title_short | Lymphomatoid papulosis in association with mycosis fungoides: A clinical and histopathologic review of five Taiwanese cases |
| title_sort | lymphomatoid papulosis in association with mycosis fungoides a clinical and histopathologic review of five taiwanese cases |
| topic | CD8+ lymphoma hypopigmented juvenile-onset lymphomatoid papulosis mycosis fungoides |
| url | http://www.sciencedirect.com/science/article/pii/S102781171300089X |
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