Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections
This data article contains complementary figures related to the research article entitled, “Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts” (Ikeda et al. (2016) [2], http://dx.doi.org/10.1016/j.bbrep.2016.06.022), which presents...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-09-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916305157 |
| _version_ | 1811195891618414592 |
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| author | Tetsurou Ikeda Maria Fragiadaki Xu Shi-wen Markella Ponticos Korsa Khan Christopher Denton Patricia Garcia George Bou-Gharios Akio Yamakawa Chikao Morimoto David Abraham |
| author_facet | Tetsurou Ikeda Maria Fragiadaki Xu Shi-wen Markella Ponticos Korsa Khan Christopher Denton Patricia Garcia George Bou-Gharios Akio Yamakawa Chikao Morimoto David Abraham |
| author_sort | Tetsurou Ikeda |
| collection | DOAJ |
| description | This data article contains complementary figures related to the research article entitled, “Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts” (Ikeda et al. (2016) [2], http://dx.doi.org/10.1016/j.bbrep.2016.06.022), which presents that TGF-β increased CUX1 binding in the proximal promoter and enhancer of the COL1A2 and regulated COL1. Further, in the scleroderma (SSc) lung and diffuse alveolar damage lung sections, CUX1 localized within the α- smooth muscle actin (α-SMA) positive cells (Fragiadaki et al., 2011) [1], “High doses of TGF-beta potently suppress type I collagen via the transcription factor CUX1” (Ikeda et al., 2016) [2]. Here we show that CUX1 isoforms are localized within α-smooth muscle actin-positive cells in SSc skin and idiopathic pulmonary fibrosis (IPF) lung tissue sections. In particular, at the granular and prickle cell layers in the SSc skin sections, CUX1 and α-SMA are co-localized. In addition, at the fibrotic loci in the IPF lung tissue sections, CUX1 localized within the α-smooth muscle actin (α-SMA) positive cells. |
| first_indexed | 2024-04-12T00:50:09Z |
| format | Article |
| id | doaj.art-3f31e14fa61c45928700fbaf7fef09b9 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-12T00:50:09Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-3f31e14fa61c45928700fbaf7fef09b92022-12-22T03:54:45ZengElsevierData in Brief2352-34092016-09-01813771380Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sectionsTetsurou Ikeda0Maria Fragiadaki1Xu Shi-wen2Markella Ponticos3Korsa Khan4Christopher Denton5Patricia Garcia6George Bou-Gharios7Akio Yamakawa8Chikao Morimoto9David Abraham10Royal Free and University College Medical School, London, UK; Imperial College School of Medicine, London, UK; University of Tokyo, Institute of Medical Science, Tokyo, Japan; Corresponding author at: University of Tokyo, Institute of Medical Science, Tokyo, Japan.Imperial College School of Medicine, London, UKRoyal Free and University College Medical School, London, UKRoyal Free and University College Medical School, London, UKRoyal Free and University College Medical School, London, UKRoyal Free and University College Medical School, London, UKRoyal Free and University College Medical School, London, UKImperial College School of Medicine, London, UKUniversity of Tokyo, Institute of Medical Science, Tokyo, JapanUniversity of Tokyo, Institute of Medical Science, Tokyo, JapanRoyal Free and University College Medical School, London, UKThis data article contains complementary figures related to the research article entitled, “Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts” (Ikeda et al. (2016) [2], http://dx.doi.org/10.1016/j.bbrep.2016.06.022), which presents that TGF-β increased CUX1 binding in the proximal promoter and enhancer of the COL1A2 and regulated COL1. Further, in the scleroderma (SSc) lung and diffuse alveolar damage lung sections, CUX1 localized within the α- smooth muscle actin (α-SMA) positive cells (Fragiadaki et al., 2011) [1], “High doses of TGF-beta potently suppress type I collagen via the transcription factor CUX1” (Ikeda et al., 2016) [2]. Here we show that CUX1 isoforms are localized within α-smooth muscle actin-positive cells in SSc skin and idiopathic pulmonary fibrosis (IPF) lung tissue sections. In particular, at the granular and prickle cell layers in the SSc skin sections, CUX1 and α-SMA are co-localized. In addition, at the fibrotic loci in the IPF lung tissue sections, CUX1 localized within the α-smooth muscle actin (α-SMA) positive cells.http://www.sciencedirect.com/science/article/pii/S2352340916305157 |
| spellingShingle | Tetsurou Ikeda Maria Fragiadaki Xu Shi-wen Markella Ponticos Korsa Khan Christopher Denton Patricia Garcia George Bou-Gharios Akio Yamakawa Chikao Morimoto David Abraham Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections Data in Brief |
| title | Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| title_full | Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| title_fullStr | Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| title_full_unstemmed | Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| title_short | Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| title_sort | data on cux1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916305157 |
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