Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application
The growing increase in antibiotic-resistant bacteria has led to the search for new antibacterial agents capable of overcoming the resistance problem. In recent years, nanoparticles (NPs) have been increasingly used to target bacteria as an alternative to antibiotics. The most promising nanomaterial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/9/1778 |
| _version_ | 1827658585552715776 |
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| author | Domenico Franco Giovanna Calabrese Salvatore Pietro Paolo Guglielmino Sabrina Conoci |
| author_facet | Domenico Franco Giovanna Calabrese Salvatore Pietro Paolo Guglielmino Sabrina Conoci |
| author_sort | Domenico Franco |
| collection | DOAJ |
| description | The growing increase in antibiotic-resistant bacteria has led to the search for new antibacterial agents capable of overcoming the resistance problem. In recent years, nanoparticles (NPs) have been increasingly used to target bacteria as an alternative to antibiotics. The most promising nanomaterials for biomedical applications are metal and metal oxide NPs, due to their intrinsic antibacterial activity. Although NPs show interesting antibacterial properties, the mechanisms underlying their action are still poorly understood, limiting their use in clinical applications. In this review, an overview of the mechanisms underlying the antibacterial activity of metal and metal oxide NPs will be provided, relating their efficacy to: (i) bacterial strain; (ii) higher microbial organizations (biofilm); (iii) and physico-chemical properties of NPs. In addition, bacterial resistance strategies will be also discussed to better evaluate the feasibility of the different treatments adopted in the clinical safety fields. Finally, a wide analysis on recent biomedical applications of metal and metal oxide NPs with antibacterial activity will be provided. |
| first_indexed | 2024-03-09T23:05:42Z |
| format | Article |
| id | doaj.art-3f32c48478814e27bdfdbf9f4fe7423b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T23:05:42Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-3f32c48478814e27bdfdbf9f4fe7423b2023-11-23T17:53:05ZengMDPI AGMicroorganisms2076-26072022-09-01109177810.3390/microorganisms10091778Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical ApplicationDomenico Franco0Giovanna Calabrese1Salvatore Pietro Paolo Guglielmino2Sabrina Conoci3Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, 98168 Messina, ItalyThe growing increase in antibiotic-resistant bacteria has led to the search for new antibacterial agents capable of overcoming the resistance problem. In recent years, nanoparticles (NPs) have been increasingly used to target bacteria as an alternative to antibiotics. The most promising nanomaterials for biomedical applications are metal and metal oxide NPs, due to their intrinsic antibacterial activity. Although NPs show interesting antibacterial properties, the mechanisms underlying their action are still poorly understood, limiting their use in clinical applications. In this review, an overview of the mechanisms underlying the antibacterial activity of metal and metal oxide NPs will be provided, relating their efficacy to: (i) bacterial strain; (ii) higher microbial organizations (biofilm); (iii) and physico-chemical properties of NPs. In addition, bacterial resistance strategies will be also discussed to better evaluate the feasibility of the different treatments adopted in the clinical safety fields. Finally, a wide analysis on recent biomedical applications of metal and metal oxide NPs with antibacterial activity will be provided.https://www.mdpi.com/2076-2607/10/9/1778antibacterial mechanismsbacterial resistancebiofilmmetal and metal oxide nanoparticlesnanotechnologynanomedicine |
| spellingShingle | Domenico Franco Giovanna Calabrese Salvatore Pietro Paolo Guglielmino Sabrina Conoci Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application Microorganisms antibacterial mechanisms bacterial resistance biofilm metal and metal oxide nanoparticles nanotechnology nanomedicine |
| title | Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application |
| title_full | Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application |
| title_fullStr | Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application |
| title_full_unstemmed | Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application |
| title_short | Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application |
| title_sort | metal based nanoparticles antibacterial mechanisms and biomedical application |
| topic | antibacterial mechanisms bacterial resistance biofilm metal and metal oxide nanoparticles nanotechnology nanomedicine |
| url | https://www.mdpi.com/2076-2607/10/9/1778 |
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