The impact of mental vulnerability on the relationship between cardiovascular disease and depression
AbstractBackground.The mechanisms linking cardiovascular disease (CVD) and depression are still not established. We investigated the impact of mental vulnerability on the relationship between CVD and depression.Methods.A total of 19,856 individuals from five cohorts of random samples of the backgrou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933820000206/type/journal_article |
| _version_ | 1827994966474883072 |
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| author | Terese Sara Høj Jørgensen Marie Kim Wium-Andersen Martin Balslev Jørgensen Merete Osler |
| author_facet | Terese Sara Høj Jørgensen Marie Kim Wium-Andersen Martin Balslev Jørgensen Merete Osler |
| author_sort | Terese Sara Høj Jørgensen |
| collection | DOAJ |
| description | AbstractBackground.The mechanisms linking cardiovascular disease (CVD) and depression are still not established. We investigated the impact of mental vulnerability on the relationship between CVD and depression.Methods.A total of 19,856 individuals from five cohorts of random samples of the background population in Copenhagen were followed from baseline (1983–2011) until 2017 in Danish registries. Additive hazard and Cox proportional hazard models were used to analyze the effects of confounding by mental vulnerability as well as interactions between mental vulnerability and CVD on the risk of depression.Results.During follow-up, 15.3% developed CVD, while 18.1% experienced depression. A strong positive association between CVD and depression (hazard ratio: 3.60 [95% confidence intervals (CI): 3.30; 3.92]) corresponding to 35.4 (95% CI: 31.7; 39.1) additional cases per 1,000 person-years was only slightly attenuated after adjustment for mental vulnerability in addition to other confounders. Synergistic interaction between CVD and mental vulnerability was identified in the additive hazard model. Due to interaction between CVD and mental vulnerability, CVD was associated with 50.9 more cases of depression per 1,000 person-years among individuals with high mental vulnerability compared with individuals with low mental vulnerability.Conclusions.Mental vulnerability did not explain the strong relationship between CVD and depression. CVD was associated with additional cases of depression among individuals with higher mental vulnerability indicating that this group holds the greatest potential for intervention, for example, in rehabilitation settings. |
| first_indexed | 2024-04-10T04:49:11Z |
| format | Article |
| id | doaj.art-3f32db19d4764723a6e5800ee8f056ea |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:49:11Z |
| publishDate | 2020-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-3f32db19d4764723a6e5800ee8f056ea2023-03-09T12:33:57ZengCambridge University PressEuropean Psychiatry0924-93381778-35852020-01-016310.1192/j.eurpsy.2020.20The impact of mental vulnerability on the relationship between cardiovascular disease and depressionTerese Sara Høj Jørgensen0https://orcid.org/0000-0003-1450-4472Marie Kim Wium-Andersen1Martin Balslev Jørgensen2Merete Osler3Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment O, Psychiatric Center Copenhagen, and Institute of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, DenmarkAbstractBackground.The mechanisms linking cardiovascular disease (CVD) and depression are still not established. We investigated the impact of mental vulnerability on the relationship between CVD and depression.Methods.A total of 19,856 individuals from five cohorts of random samples of the background population in Copenhagen were followed from baseline (1983–2011) until 2017 in Danish registries. Additive hazard and Cox proportional hazard models were used to analyze the effects of confounding by mental vulnerability as well as interactions between mental vulnerability and CVD on the risk of depression.Results.During follow-up, 15.3% developed CVD, while 18.1% experienced depression. A strong positive association between CVD and depression (hazard ratio: 3.60 [95% confidence intervals (CI): 3.30; 3.92]) corresponding to 35.4 (95% CI: 31.7; 39.1) additional cases per 1,000 person-years was only slightly attenuated after adjustment for mental vulnerability in addition to other confounders. Synergistic interaction between CVD and mental vulnerability was identified in the additive hazard model. Due to interaction between CVD and mental vulnerability, CVD was associated with 50.9 more cases of depression per 1,000 person-years among individuals with high mental vulnerability compared with individuals with low mental vulnerability.Conclusions.Mental vulnerability did not explain the strong relationship between CVD and depression. CVD was associated with additional cases of depression among individuals with higher mental vulnerability indicating that this group holds the greatest potential for intervention, for example, in rehabilitation settings.https://www.cambridge.org/core/product/identifier/S0924933820000206/type/journal_articlecardiovascular diseasedepressionepidemiologyinteraction analysesmental vulnerability |
| spellingShingle | Terese Sara Høj Jørgensen Marie Kim Wium-Andersen Martin Balslev Jørgensen Merete Osler The impact of mental vulnerability on the relationship between cardiovascular disease and depression European Psychiatry cardiovascular disease depression epidemiology interaction analyses mental vulnerability |
| title | The impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| title_full | The impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| title_fullStr | The impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| title_full_unstemmed | The impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| title_short | The impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| title_sort | impact of mental vulnerability on the relationship between cardiovascular disease and depression |
| topic | cardiovascular disease depression epidemiology interaction analyses mental vulnerability |
| url | https://www.cambridge.org/core/product/identifier/S0924933820000206/type/journal_article |
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