Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study
Objective: To investigate the association between anti-phospholipid syndrome (APS) and the risk of newly diagnosed systemic lupus erythematosus (SLE).Methods: We used 2003–2013 data derived from Taiwan's National Health Insurance Research Database to conduct this nationwide, population-based. W...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.654791/full |
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| author | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao |
| author_facet | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao |
| author_sort | Hsin-Hua Chen |
| collection | DOAJ |
| description | Objective: To investigate the association between anti-phospholipid syndrome (APS) and the risk of newly diagnosed systemic lupus erythematosus (SLE).Methods: We used 2003–2013 data derived from Taiwan's National Health Insurance Research Database to conduct this nationwide, population-based. We identified AS patients newly diagnosed between 2005 to 2013 as the study group and applied age-sex matched (1:20) and propensity score-matched (PSM) (1:2) non-SLE individuals as controls. The association between APS and risk of incident SLE was determined by calculating hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazard regression analysis.Results: We identified 1,245 patients with APS as well as 24,900 age- and sex-matched non-APS controls and 727 APS patients as well as 1,454 PSM non-APS controls. We found that the risk for incident SLE in the APS group was 80.70 times higher than the non-APS group, and the association remained robust after PSM (HR, 28.55; 95% CI, 11.49–70.91). The increased risk for SLE in patients with APS mainly existed within 5 years after the diagnosis of APS. The sensitivity analyses found that the risk for SLE in patients with APS was consistent excluding patients with ITP/AIHA and using distinct definitions of SLE.Conclusion: The present population-based study revealed a robust association between SLE risk and recent APS and highlights the need for vigilance of SLE-associated symptoms in patients who had been diagnosed with APS. |
| first_indexed | 2024-12-16T15:02:06Z |
| format | Article |
| id | doaj.art-3f336c890ce245e3bce40199a2d47fc6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-16T15:02:06Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3f336c890ce245e3bce40199a2d47fc62022-12-21T22:27:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-05-01810.3389/fmed.2021.654791654791Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based StudyHsin-Hua Chen0Hsin-Hua Chen1Hsin-Hua Chen2Hsin-Hua Chen3Hsin-Hua Chen4Ching-Heng Lin5Ching-Heng Lin6Ching-Heng Lin7Ching-Heng Lin8Wen-Cheng Chao9Wen-Cheng Chao10Wen-Cheng Chao11Department of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanInstitute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, TaiwanDepartment of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, TaiwanInstitute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, TaiwanDepartment of Healthcare Management, National Taipei University of Nursing and Health Sciences, Taipei, TaiwanDepartment of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanDepartment of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Computer Science, Tunghai University, Taichung, Taiwan0Department of Automatic Control Engineering, Feng Chia University, Taichung, TaiwanObjective: To investigate the association between anti-phospholipid syndrome (APS) and the risk of newly diagnosed systemic lupus erythematosus (SLE).Methods: We used 2003–2013 data derived from Taiwan's National Health Insurance Research Database to conduct this nationwide, population-based. We identified AS patients newly diagnosed between 2005 to 2013 as the study group and applied age-sex matched (1:20) and propensity score-matched (PSM) (1:2) non-SLE individuals as controls. The association between APS and risk of incident SLE was determined by calculating hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox proportional hazard regression analysis.Results: We identified 1,245 patients with APS as well as 24,900 age- and sex-matched non-APS controls and 727 APS patients as well as 1,454 PSM non-APS controls. We found that the risk for incident SLE in the APS group was 80.70 times higher than the non-APS group, and the association remained robust after PSM (HR, 28.55; 95% CI, 11.49–70.91). The increased risk for SLE in patients with APS mainly existed within 5 years after the diagnosis of APS. The sensitivity analyses found that the risk for SLE in patients with APS was consistent excluding patients with ITP/AIHA and using distinct definitions of SLE.Conclusion: The present population-based study revealed a robust association between SLE risk and recent APS and highlights the need for vigilance of SLE-associated symptoms in patients who had been diagnosed with APS.https://www.frontiersin.org/articles/10.3389/fmed.2021.654791/fullanti-phospholipid syndromesystemic lupus erythematosusautoimmune diseasesriskpropensity matching |
| spellingShingle | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study Frontiers in Medicine anti-phospholipid syndrome systemic lupus erythematosus autoimmune diseases risk propensity matching |
| title | Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study |
| title_full | Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study |
| title_fullStr | Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study |
| title_full_unstemmed | Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study |
| title_short | Risk of Systemic Lupus Erythematosus in Patients With Anti-phospholipid Syndrome: A Population-Based Study |
| title_sort | risk of systemic lupus erythematosus in patients with anti phospholipid syndrome a population based study |
| topic | anti-phospholipid syndrome systemic lupus erythematosus autoimmune diseases risk propensity matching |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.654791/full |
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