Features of transfusion therapy in hematopoietic stem cell transplantation
The aim of the research is to identify factors influencing the safety and efficacy of the transfusion therapy with hematopoietic stem cell transplantation (HSCT). From January 1 to December 31, 2015, 329 patients with hematologic diseases and malignancies who had undergone 367 HSCT were included int...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Academician I.P. Pavlov First St. Petersburg State Medical University
2016-12-01
|
| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| Subjects: | |
| Online Access: | https://www.sci-notes.ru/jour/article/view/363 |
| _version_ | 1826560791120183296 |
|---|---|
| author | M. A. Kucher D. E. Pevtcov M. A. Estrina N. E. Ivanova O. A. Makarenko B. A. Barishev B. V. Afanasyev |
| author_facet | M. A. Kucher D. E. Pevtcov M. A. Estrina N. E. Ivanova O. A. Makarenko B. A. Barishev B. V. Afanasyev |
| author_sort | M. A. Kucher |
| collection | DOAJ |
| description | The aim of the research is to identify factors influencing the safety and efficacy of the transfusion therapy with hematopoietic stem cell transplantation (HSCT). From January 1 to December 31, 2015, 329 patients with hematologic diseases and malignancies who had undergone 367 HSCT were included into the study. Transfusion therapy was conducted in 345 HSCT – 94 % of cases. Totally, 9074 cases of transfusion of blood components were recorded: red blood cellcontaining – 2378 (26.2 %), plateletcontaining – 6255 (68.9 %), fresh frozen plasma – 441 (4.9 %). АВ0incompatibility between the donor and recipient was determined in 60.4 % of cases (n=154) in HSCT from allogeneic donor. Acute «graft versus host disease» was observed in 34.9 % of cases (n=89). Hemorrhagic complications were in 46 cases (12.5 %), mainly nasal, gastrointestinal bleeding and hemorrhagic cystitis. Pprevention and treatment of anemic and hemorrhagic complications in HSCT requires longterm and massive transfusion therapy with the availability of АВ0-incompatibility. The use of leukofiltrated, γ - or x-ray irradiated, individually and immunologically compatible blood components can reduce the risk of development of acute and delayed transfusion reactions in HSCT. |
| first_indexed | 2024-03-12T03:41:31Z |
| format | Article |
| id | doaj.art-3f3391f07ccd4abb928849725b7a0acd |
| institution | Directory Open Access Journal |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| last_indexed | 2025-03-14T09:21:53Z |
| publishDate | 2016-12-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-3f3391f07ccd4abb928849725b7a0acd2025-03-02T11:44:13ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072016-12-01234616510.24884/1607-4181-2016-23-4-61-65318Features of transfusion therapy in hematopoietic stem cell transplantationM. A. Kucher0D. E. Pevtcov1M. A. Estrina2N. E. Ivanova3O. A. Makarenko4B. A. Barishev5B. V. Afanasyev6Pavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgPavlov First State Medical University of St. PetersburgThe aim of the research is to identify factors influencing the safety and efficacy of the transfusion therapy with hematopoietic stem cell transplantation (HSCT). From January 1 to December 31, 2015, 329 patients with hematologic diseases and malignancies who had undergone 367 HSCT were included into the study. Transfusion therapy was conducted in 345 HSCT – 94 % of cases. Totally, 9074 cases of transfusion of blood components were recorded: red blood cellcontaining – 2378 (26.2 %), plateletcontaining – 6255 (68.9 %), fresh frozen plasma – 441 (4.9 %). АВ0incompatibility between the donor and recipient was determined in 60.4 % of cases (n=154) in HSCT from allogeneic donor. Acute «graft versus host disease» was observed in 34.9 % of cases (n=89). Hemorrhagic complications were in 46 cases (12.5 %), mainly nasal, gastrointestinal bleeding and hemorrhagic cystitis. Pprevention and treatment of anemic and hemorrhagic complications in HSCT requires longterm and massive transfusion therapy with the availability of АВ0-incompatibility. The use of leukofiltrated, γ - or x-ray irradiated, individually and immunologically compatible blood components can reduce the risk of development of acute and delayed transfusion reactions in HSCT.https://www.sci-notes.ru/jour/article/view/363hematopoietic stem cell transplantationtransfusion therapy |
| spellingShingle | M. A. Kucher D. E. Pevtcov M. A. Estrina N. E. Ivanova O. A. Makarenko B. A. Barishev B. V. Afanasyev Features of transfusion therapy in hematopoietic stem cell transplantation Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова hematopoietic stem cell transplantation transfusion therapy |
| title | Features of transfusion therapy in hematopoietic stem cell transplantation |
| title_full | Features of transfusion therapy in hematopoietic stem cell transplantation |
| title_fullStr | Features of transfusion therapy in hematopoietic stem cell transplantation |
| title_full_unstemmed | Features of transfusion therapy in hematopoietic stem cell transplantation |
| title_short | Features of transfusion therapy in hematopoietic stem cell transplantation |
| title_sort | features of transfusion therapy in hematopoietic stem cell transplantation |
| topic | hematopoietic stem cell transplantation transfusion therapy |
| url | https://www.sci-notes.ru/jour/article/view/363 |
| work_keys_str_mv | AT makucher featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT depevtcov featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT maestrina featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT neivanova featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT oamakarenko featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT babarishev featuresoftransfusiontherapyinhematopoieticstemcelltransplantation AT bvafanasyev featuresoftransfusiontherapyinhematopoieticstemcelltransplantation |