Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection
Key points Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group. These findings indicate the importance of increasing TNF-α with Th1...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-022-01456-0 |
| _version_ | 1798004424714485760 |
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| author | Ghorbanali Rahimian Milad Shahini Shams Abadi Yousef Mirzaei Ali Hussein Mer Reza Ahmadi Fatemeh Azadegan-Dehkordi |
| author_facet | Ghorbanali Rahimian Milad Shahini Shams Abadi Yousef Mirzaei Ali Hussein Mer Reza Ahmadi Fatemeh Azadegan-Dehkordi |
| author_sort | Ghorbanali Rahimian |
| collection | DOAJ |
| description | Key points Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group. These findings indicate the importance of increasing TNF-α with Th1, Th17, Th22 responses increase as an important risk factor for PUD in context of H. pylori infection. |
| first_indexed | 2024-04-11T12:23:27Z |
| format | Article |
| id | doaj.art-3f3400e49d2d48ffb7675876b510dfa0 |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-04-11T12:23:27Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-3f3400e49d2d48ffb7675876b510dfa02022-12-22T04:24:01ZengSpringerOpenAMB Express2191-08552022-09-0112111110.1186/s13568-022-01456-0Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infectionGhorbanali Rahimian0Milad Shahini Shams Abadi1Yousef Mirzaei2Ali Hussein Mer3Reza Ahmadi4Fatemeh Azadegan-Dehkordi5Department of Internal Medicine, Shahrekord University of Medical SciencesCellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical SciencesDepartment of Medical Biochemical Analysis, Cihan University-ErbilScientific Research Center, Soran UniversityClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical SciencesCellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical SciencesKey points Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group. These findings indicate the importance of increasing TNF-α with Th1, Th17, Th22 responses increase as an important risk factor for PUD in context of H. pylori infection.https://doi.org/10.1186/s13568-022-01456-0Helicobacter pyloriTNF-αT helperPeptic ulcer diseaseGastritisVirulence factors |
| spellingShingle | Ghorbanali Rahimian Milad Shahini Shams Abadi Yousef Mirzaei Ali Hussein Mer Reza Ahmadi Fatemeh Azadegan-Dehkordi Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection AMB Express Helicobacter pylori TNF-α T helper Peptic ulcer disease Gastritis Virulence factors |
| title | Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection |
| title_full | Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection |
| title_fullStr | Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection |
| title_full_unstemmed | Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection |
| title_short | Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection |
| title_sort | relationship between mucosal tnf α expression and th1 th17 th22 and treg responses in helicobacter pylori infection |
| topic | Helicobacter pylori TNF-α T helper Peptic ulcer disease Gastritis Virulence factors |
| url | https://doi.org/10.1186/s13568-022-01456-0 |
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