Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases

Imbalance in Renal Vasoactive Enzymes Induced by Mild Hypoxia: Angiotensin-Converting Enzyme Increases While Neutral Endopeptidase Decreases

Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-angiotensin and the kallikrein–kinin systems,...

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Bibliographic Details
Main Authors: Carlos P. Vio, Daniela Salas, Carlos Cespedes, Jessica Diaz-Elizondo, Natalia Mendez, Julio Alcayaga, Rodrigo Iturriaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
renal hypoxia
kallikrein
angiotensin-converting enzyme
neprilysin
neutral endopeptidase
subtle renal injury
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01791/full

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