HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer

HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer

Abstract E3 ligase is widely reported to exert fundamental functions in cancers. Through rigorous bioinformatic analysis concentrating E3 ligases based on data from Genotype-Tissue Expression (GTEx) and data from The Cancer Genome Atlas (TCGA), HERC3 was indicated to be downregulated in colorectal c...

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Bibliographic Details
Main Authors: Zhiyuan Zhang, Guodong He, Yang Lv, Yu Liu, Zhengchuan Niu, Qingyang Feng, Ronggui Hu, Jianmin Xu
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04511-7

Internet

https://doi.org/10.1038/s41419-022-04511-7

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