Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications
The mutualistic relationship between human health and gut microbiota has gained growing attention as a result of its far-reaching consequences. Diabetes medications, essential for managing type 2 diabetes, which regulate glucose metabolism, have shown effects that go beyond glycemic control by recei...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Diabetes Epidemiology and Management |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666970623000598 |
| _version_ | 1797320885679423488 |
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| author | Venkata Chaithanya Janardanan Kumar Kakithakara Vajravelu Leela Matcha Angelin Abhishek Satheesan Ria Murugesan |
| author_facet | Venkata Chaithanya Janardanan Kumar Kakithakara Vajravelu Leela Matcha Angelin Abhishek Satheesan Ria Murugesan |
| author_sort | Venkata Chaithanya |
| collection | DOAJ |
| description | The mutualistic relationship between human health and gut microbiota has gained growing attention as a result of its far-reaching consequences. Diabetes medications, essential for managing type 2 diabetes, which regulate glucose metabolism, have shown effects that go beyond glycemic control by receiving attention for their possible influence on gut microbiota. Notably, metformin, a cornerstone therapy, has received a lot of attention for its ability to influence the gut microbiota. Metformin administration has been linked to changes in the abundance of specific bacterial taxa, including an uprise in beneficial microbes like Akkermansia muciniphila. These modifications have been linked to increased insulin sensitivity and better metabolic outcomes. Other classes of diabetes drugs, in addition to metformin, have shown potential effects on the gut microbiota. SGLT-2 inhibitors, for example, may contribute to changes in gut microbial communities, which could explain their cardiovascular and metabolic benefits. However, the processes underlying these interactions, are complicated and not entirely understood. Direct interactions between the gut microbiota and drug, changes in intestinal permeability, and modulation of bile acid metabolism are all possible mechanisms. Individual differences and genetic factors complicate the relationship even more. Understanding the intricate interplay between diabetes drugs and gut microbiota holds promise for developing personalized diabetes management approaches. Taking advantage of these interactions could lead to novel therapeutic strategies that improve drug efficacy and overall metabolic health. More studies are required to determine the exact mechanisms underlying these effects and to capitalize on their potential for improved patient outcomes. This review provides a concise overview of the effects of diabetes medications on gut microbiota composition and its importance. |
| first_indexed | 2024-03-08T04:49:32Z |
| format | Article |
| id | doaj.art-3f361205683444029bb2c66f3869998f |
| institution | Directory Open Access Journal |
| issn | 2666-9706 |
| language | English |
| last_indexed | 2024-03-08T04:49:32Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Diabetes Epidemiology and Management |
| spelling | doaj.art-3f361205683444029bb2c66f3869998f2024-02-08T05:18:24ZengElsevierDiabetes Epidemiology and Management2666-97062024-01-0113100180Metabolic consequences of alterations in gut microbiota induced by antidiabetic medicationsVenkata Chaithanya0Janardanan Kumar1Kakithakara Vajravelu Leela2Matcha Angelin3Abhishek Satheesan4Ria Murugesan5Department of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, IndiaDepartment of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, India; Corresponding author.Department of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, IndiaDepartment of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, IndiaDepartment of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, IndiaDepartment of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chengalapattu, Tamil Nadu 603203, IndiaThe mutualistic relationship between human health and gut microbiota has gained growing attention as a result of its far-reaching consequences. Diabetes medications, essential for managing type 2 diabetes, which regulate glucose metabolism, have shown effects that go beyond glycemic control by receiving attention for their possible influence on gut microbiota. Notably, metformin, a cornerstone therapy, has received a lot of attention for its ability to influence the gut microbiota. Metformin administration has been linked to changes in the abundance of specific bacterial taxa, including an uprise in beneficial microbes like Akkermansia muciniphila. These modifications have been linked to increased insulin sensitivity and better metabolic outcomes. Other classes of diabetes drugs, in addition to metformin, have shown potential effects on the gut microbiota. SGLT-2 inhibitors, for example, may contribute to changes in gut microbial communities, which could explain their cardiovascular and metabolic benefits. However, the processes underlying these interactions, are complicated and not entirely understood. Direct interactions between the gut microbiota and drug, changes in intestinal permeability, and modulation of bile acid metabolism are all possible mechanisms. Individual differences and genetic factors complicate the relationship even more. Understanding the intricate interplay between diabetes drugs and gut microbiota holds promise for developing personalized diabetes management approaches. Taking advantage of these interactions could lead to novel therapeutic strategies that improve drug efficacy and overall metabolic health. More studies are required to determine the exact mechanisms underlying these effects and to capitalize on their potential for improved patient outcomes. This review provides a concise overview of the effects of diabetes medications on gut microbiota composition and its importance.http://www.sciencedirect.com/science/article/pii/S2666970623000598DiabetesGut microbiotaDiabetes medicationsMetformin |
| spellingShingle | Venkata Chaithanya Janardanan Kumar Kakithakara Vajravelu Leela Matcha Angelin Abhishek Satheesan Ria Murugesan Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications Diabetes Epidemiology and Management Diabetes Gut microbiota Diabetes medications Metformin |
| title | Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| title_full | Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| title_fullStr | Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| title_full_unstemmed | Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| title_short | Metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| title_sort | metabolic consequences of alterations in gut microbiota induced by antidiabetic medications |
| topic | Diabetes Gut microbiota Diabetes medications Metformin |
| url | http://www.sciencedirect.com/science/article/pii/S2666970623000598 |
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