Molecular mechanisms of tumor resistance to radiotherapy
Abstract Background Cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. Resistance to radiation can lead to local treatment failure and even cance...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01801-2 |
| _version_ | 1797801564699623424 |
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| author | Yu Wu Yingqiu Song Runze Wang Tianlu Wang |
| author_facet | Yu Wu Yingqiu Song Runze Wang Tianlu Wang |
| author_sort | Yu Wu |
| collection | DOAJ |
| description | Abstract Background Cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. Resistance to radiation can lead to local treatment failure and even cancer recurrence. Main body In this review, we have extensively discussed several crucial aspects that cause resistance of cancer to radiation therapy, including radiation-induced DNA damage repair, cell cycle arrest, apoptosis escape, abundance of cancer stem cells, modification of cancer cells and their microenvironment, presence of exosomal and non-coding RNA, metabolic reprogramming, and ferroptosis. We aim to focus on the molecular mechanisms of cancer radiotherapy resistance in relation to these aspects and to discuss possible targets to improve treatment outcomes. Conclusions Studying the molecular mechanisms responsible for radiotherapy resistance and its interactions with the tumor environment will help improve cancer responses to radiotherapy. Our review provides a foundation to identify and overcome the obstacles to effective radiotherapy. |
| first_indexed | 2024-03-13T04:52:15Z |
| format | Article |
| id | doaj.art-3f364ec2b0f24019a7d92d5777eaee55 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-03-13T04:52:15Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-3f364ec2b0f24019a7d92d5777eaee552023-06-18T11:08:24ZengBMCMolecular Cancer1476-45982023-06-0122112110.1186/s12943-023-01801-2Molecular mechanisms of tumor resistance to radiotherapyYu Wu0Yingqiu Song1Runze Wang2Tianlu Wang3Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of TechnologyDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of TechnologyDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of TechnologyDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of TechnologyAbstract Background Cancer is the most prevalent cause of death globally, and radiotherapy is considered the standard of care for most solid tumors, including lung, breast, esophageal, and colorectal cancers and glioblastoma. Resistance to radiation can lead to local treatment failure and even cancer recurrence. Main body In this review, we have extensively discussed several crucial aspects that cause resistance of cancer to radiation therapy, including radiation-induced DNA damage repair, cell cycle arrest, apoptosis escape, abundance of cancer stem cells, modification of cancer cells and their microenvironment, presence of exosomal and non-coding RNA, metabolic reprogramming, and ferroptosis. We aim to focus on the molecular mechanisms of cancer radiotherapy resistance in relation to these aspects and to discuss possible targets to improve treatment outcomes. Conclusions Studying the molecular mechanisms responsible for radiotherapy resistance and its interactions with the tumor environment will help improve cancer responses to radiotherapy. Our review provides a foundation to identify and overcome the obstacles to effective radiotherapy.https://doi.org/10.1186/s12943-023-01801-2CancerRadiotherapyTumor resistance |
| spellingShingle | Yu Wu Yingqiu Song Runze Wang Tianlu Wang Molecular mechanisms of tumor resistance to radiotherapy Molecular Cancer Cancer Radiotherapy Tumor resistance |
| title | Molecular mechanisms of tumor resistance to radiotherapy |
| title_full | Molecular mechanisms of tumor resistance to radiotherapy |
| title_fullStr | Molecular mechanisms of tumor resistance to radiotherapy |
| title_full_unstemmed | Molecular mechanisms of tumor resistance to radiotherapy |
| title_short | Molecular mechanisms of tumor resistance to radiotherapy |
| title_sort | molecular mechanisms of tumor resistance to radiotherapy |
| topic | Cancer Radiotherapy Tumor resistance |
| url | https://doi.org/10.1186/s12943-023-01801-2 |
| work_keys_str_mv | AT yuwu molecularmechanismsoftumorresistancetoradiotherapy AT yingqiusong molecularmechanismsoftumorresistancetoradiotherapy AT runzewang molecularmechanismsoftumorresistancetoradiotherapy AT tianluwang molecularmechanismsoftumorresistancetoradiotherapy |