Some Perspectives on Network Modeling in Therapeutic Target Prediction
Drug target identification is of significant commercial interest to pharmaceutical companies, and there is a vast amount of research done related to the topic of therapeutic target identification. Interdisciplinary research in this area involves both the biological network community and the graph al...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-01-01
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| Series: | Biomedical Engineering and Computational Biology |
| Online Access: | https://doi.org/10.4137/BECB.S10793 |
| _version_ | 1828759184483549184 |
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| author | Reka Albert Bhaskar DasGupta Nasim Mobasheri |
| author_facet | Reka Albert Bhaskar DasGupta Nasim Mobasheri |
| author_sort | Reka Albert |
| collection | DOAJ |
| description | Drug target identification is of significant commercial interest to pharmaceutical companies, and there is a vast amount of research done related to the topic of therapeutic target identification. Interdisciplinary research in this area involves both the biological network community and the graph algorithms community. Key steps of a typical therapeutic target identification problem include synthesizing or inferring the complex network of interactions relevant to the disease, connecting this network to the disease-specific behavior, and predicting which components are key mediators of the behavior. All of these steps involve graph theoretical or graph algorithmic aspects. In this perspective, we provide modelling and algorithmic perspectives for therapeutic target identification and highlight a number of algorithmic advances, which have gotten relatively little attention so far, with the hope of strengthening the ties between these two research communities. |
| first_indexed | 2024-12-11T00:53:36Z |
| format | Article |
| id | doaj.art-3f3715dda65f49ebb7d36bf2306d2175 |
| institution | Directory Open Access Journal |
| issn | 1179-5972 |
| language | English |
| last_indexed | 2024-12-11T00:53:36Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomedical Engineering and Computational Biology |
| spelling | doaj.art-3f3715dda65f49ebb7d36bf2306d21752022-12-22T01:26:33ZengSAGE PublishingBiomedical Engineering and Computational Biology1179-59722013-01-01510.4137/BECB.S10793Some Perspectives on Network Modeling in Therapeutic Target PredictionReka Albert0Bhaskar DasGupta1Nasim Mobasheri2Department of Physics, Pennsylvania State University, University Park, PA.Department of Computer Science, University of Illinois at Chicago, Chicago, IL.Department of Computer Science, University of Illinois at Chicago, Chicago, IL.Drug target identification is of significant commercial interest to pharmaceutical companies, and there is a vast amount of research done related to the topic of therapeutic target identification. Interdisciplinary research in this area involves both the biological network community and the graph algorithms community. Key steps of a typical therapeutic target identification problem include synthesizing or inferring the complex network of interactions relevant to the disease, connecting this network to the disease-specific behavior, and predicting which components are key mediators of the behavior. All of these steps involve graph theoretical or graph algorithmic aspects. In this perspective, we provide modelling and algorithmic perspectives for therapeutic target identification and highlight a number of algorithmic advances, which have gotten relatively little attention so far, with the hope of strengthening the ties between these two research communities.https://doi.org/10.4137/BECB.S10793 |
| spellingShingle | Reka Albert Bhaskar DasGupta Nasim Mobasheri Some Perspectives on Network Modeling in Therapeutic Target Prediction Biomedical Engineering and Computational Biology |
| title | Some Perspectives on Network Modeling in Therapeutic Target Prediction |
| title_full | Some Perspectives on Network Modeling in Therapeutic Target Prediction |
| title_fullStr | Some Perspectives on Network Modeling in Therapeutic Target Prediction |
| title_full_unstemmed | Some Perspectives on Network Modeling in Therapeutic Target Prediction |
| title_short | Some Perspectives on Network Modeling in Therapeutic Target Prediction |
| title_sort | some perspectives on network modeling in therapeutic target prediction |
| url | https://doi.org/10.4137/BECB.S10793 |
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