The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
<p>Abstract</p> <p>Background</p> <p>Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA) synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital role in immunity and inflammation. Variants in the Fatty Acid Desatu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-05-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/12/50 |
| _version_ | 1828396101759139840 |
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| author | Rudock Megan E Freedman Barry I Yanek Lisa R Case Douglas Ivester Priscilla Ziegler Julie T Suktitipat Bhoom Vaidya Dhananjay Kubala Meghan Hugenschmidt Christina E Torgerson Dara G Ruczinski Ingo Sergeant Susan Mathias Rasika A Barnes Kathleen C Langefeld Carl D Becker Lewis C Bowden Donald W Becker Diane M Chilton Floyd H |
| author_facet | Rudock Megan E Freedman Barry I Yanek Lisa R Case Douglas Ivester Priscilla Ziegler Julie T Suktitipat Bhoom Vaidya Dhananjay Kubala Meghan Hugenschmidt Christina E Torgerson Dara G Ruczinski Ingo Sergeant Susan Mathias Rasika A Barnes Kathleen C Langefeld Carl D Becker Lewis C Bowden Donald W Becker Diane M Chilton Floyd H |
| author_sort | Rudock Megan E |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA) synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital role in immunity and inflammation. Variants in the Fatty Acid Desaturase (<it>FADS</it>) family of genes on chromosome 11q have been shown to play a role in PUFA metabolism in populations of European and Asian ancestry; no work has been done in populations of African ancestry to date.</p> <p>Results</p> <p>In this study, we report that African Americans have significantly higher circulating levels of plasma AA (p = 1.35 × 10<sup>-48</sup>) and lower DGLA levels (p = 9.80 × 10<sup>-11</sup>) than European Americans. Tests for association in N = 329 individuals across 80 nucleotide polymorphisms (SNPs) in the Fatty Acid Desaturase (<it>FADS</it>) locus revealed significant association with AA, DGLA and the AA/DGLA ratio, a measure of enzymatic efficiency, in both racial groups (peak signal p = 2.85 × 10<sup>-16 </sup>in African Americans, 2.68 × 10<sup>-23 </sup>in European Americans). Ancestry-related differences were observed at an upstream marker previously associated with AA levels (rs174537), wherein, 79-82% of African Americans carry two copies of the G allele compared to only 42-45% of European Americans. Importantly, the allelic effect of the G allele, which is associated with <it>enhanced </it>conversion of DGLA to AA, on enzymatic efficiency was similar in both groups.</p> <p>Conclusions</p> <p>We conclude that the impact of <it>FADS </it>genetic variants on PUFA metabolism, specifically AA levels, is likely more pronounced in African Americans due to the larger proportion of individuals carrying the genotype associated with increased FADS1 enzymatic conversion of DGLA to AA.</p> |
| first_indexed | 2024-12-10T08:24:30Z |
| format | Article |
| id | doaj.art-3f37454bb03049a891f7188cca3d3ae9 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-12-10T08:24:30Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-3f37454bb03049a891f7188cca3d3ae92022-12-22T01:56:16ZengBMCBMC Genetics1471-21562011-05-011215010.1186/1471-2156-12-50The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African AmericansRudock Megan EFreedman Barry IYanek Lisa RCase DouglasIvester PriscillaZiegler Julie TSuktitipat BhoomVaidya DhananjayKubala MeghanHugenschmidt Christina ETorgerson Dara GRuczinski IngoSergeant SusanMathias Rasika ABarnes Kathleen CLangefeld Carl DBecker Lewis CBowden Donald WBecker Diane MChilton Floyd H<p>Abstract</p> <p>Background</p> <p>Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA) synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital role in immunity and inflammation. Variants in the Fatty Acid Desaturase (<it>FADS</it>) family of genes on chromosome 11q have been shown to play a role in PUFA metabolism in populations of European and Asian ancestry; no work has been done in populations of African ancestry to date.</p> <p>Results</p> <p>In this study, we report that African Americans have significantly higher circulating levels of plasma AA (p = 1.35 × 10<sup>-48</sup>) and lower DGLA levels (p = 9.80 × 10<sup>-11</sup>) than European Americans. Tests for association in N = 329 individuals across 80 nucleotide polymorphisms (SNPs) in the Fatty Acid Desaturase (<it>FADS</it>) locus revealed significant association with AA, DGLA and the AA/DGLA ratio, a measure of enzymatic efficiency, in both racial groups (peak signal p = 2.85 × 10<sup>-16 </sup>in African Americans, 2.68 × 10<sup>-23 </sup>in European Americans). Ancestry-related differences were observed at an upstream marker previously associated with AA levels (rs174537), wherein, 79-82% of African Americans carry two copies of the G allele compared to only 42-45% of European Americans. Importantly, the allelic effect of the G allele, which is associated with <it>enhanced </it>conversion of DGLA to AA, on enzymatic efficiency was similar in both groups.</p> <p>Conclusions</p> <p>We conclude that the impact of <it>FADS </it>genetic variants on PUFA metabolism, specifically AA levels, is likely more pronounced in African Americans due to the larger proportion of individuals carrying the genotype associated with increased FADS1 enzymatic conversion of DGLA to AA.</p>http://www.biomedcentral.com/1471-2156/12/50 |
| spellingShingle | Rudock Megan E Freedman Barry I Yanek Lisa R Case Douglas Ivester Priscilla Ziegler Julie T Suktitipat Bhoom Vaidya Dhananjay Kubala Meghan Hugenschmidt Christina E Torgerson Dara G Ruczinski Ingo Sergeant Susan Mathias Rasika A Barnes Kathleen C Langefeld Carl D Becker Lewis C Bowden Donald W Becker Diane M Chilton Floyd H The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans BMC Genetics |
| title | The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans |
| title_full | The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans |
| title_fullStr | The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans |
| title_full_unstemmed | The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans |
| title_short | The impact of <it>FADS </it>genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans |
| title_sort | impact of it fads it genetic variants on ω6 polyunsaturated fatty acid metabolism in african americans |
| url | http://www.biomedcentral.com/1471-2156/12/50 |
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